In vitro antifungal susceptibility of Candida.

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dc.contributor.authorChakrabarti, Aen_US
dc.contributor.authorGhosh, Aen_US
dc.contributor.authorKanta, Aen_US
dc.contributor.authorKumar, Pen_US
dc.date.accessioned1995-07-01en_US
dc.date.accessioned2009-05-27T06:28:01Z
dc.date.available1995-07-01en_US
dc.date.available2009-05-27T06:28:01Z
dc.date.issued1995-07-01en_US
dc.description.abstractTo develop a simple, standardised procedure for antifungal susceptibility of yeasts, disc diffusion test was evaluated in comparison to agar dilution and the macrobroth dilution procedure of the National Committee for Clinical Laboratory Standards USA. One hundred Candida strains isolated from clinical material were used against four antifungal agents (amphotericin B, 5-flucytosine, ketoconazole and fluconazole). Inoculum size of 10(6) yeasts/ml just failed to produce confluent colonies at 37 degrees C after 48 h on yeast nitrogen-glucose-agar with or without asparagine medium. The zones of inhibition were correlated with both broth and agar dilution minimum inhibitory concentrations (MICs). The results were found to correlate well using amphotericin B, 5-flucytosine and fluconazole (with broth dilution only). But there was no significant correlation using ketoconazole. Therefore, disc diffusion susceptibility testing of Candida strains appears to be generally applicable except for azoles where broth dilution test would confirm the resistant isolates.en_US
dc.description.affiliationDepartment of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh.en_US
dc.identifier.citationChakrabarti A, Ghosh A, Kanta A, Kumar P. In vitro antifungal susceptibility of Candida. Indian Journal of Medical Research. 1995 Jul; 102(): 13-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16370
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAntifungal Agents --pharmacologyen_US
dc.subject.meshCandida --drug effectsen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.titleIn vitro antifungal susceptibility of Candida.en_US
dc.typeJournal Articleen_US
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