Determination of Clinical and Radiological severity of COVID- 19 infection among vaccinated and non-vaccinated patients: A retrospective study in a tertiary care hospital

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dc.contributor.authorT, Ien_US
dc.contributor.authorS, Men_US
dc.contributor.authorD, Pen_US
dc.contributor.authorSiddeswarswamyen_US
dc.contributor.authorD, L.en_US
dc.date.accessioned2025-05-14T09:32:52Z
dc.date.available2025-05-14T09:32:52Z
dc.date.issued2024-12
dc.description.abstractBackground: The COVID-19 pandemic has spurred global efforts for vaccination. Understanding the severity of infection among vaccinated and non-vaccinated individuals can inform clinical practice and public health measures. Objective: To compare the clinical and radiological severity of COVID-19 infections between vaccinated and non-vaccinated patients in a tertiary care hospital setting. Methods: A retrospective review of patient records from January to December 2022 at Sri Siddhartha Medical Col- lege and Research Centre, tertiary care centre. Clinical severity was categorized as mild, moderate, or severe based on WHO guidelines. Radiological severity was evaluated based on standard CT severity scores. Comparisons were made between the two groups, adjusting for confounding variables like age, gender, and comorbidities. Results: In a study of 150 individuals, 100 had received the vaccine while 50 had not. Those who were vaccinated displayed markedly fewer severe clinical symptoms (p < 0.001) and demonstrated decreased CT severity scores (p < 0.005) when compared to the non-vaccinated group. Though age and pre-existing health conditions played a role in the severity of symptoms, the vaccine’s protective benefits were still pronounced after accounting for these factors. Conclusion: Vaccination against COVID-19 significantly reduces the clinical and radiological severity of the disease in patients. This study underscores the importance of widespread vaccination to mitigate the impact of the virus on individual health and hospital resources.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Siddaganga Medical College & Research Institute, Tumkur, Karnatakaen_US
dc.identifier.affiliationsBGS AMCH, Bangaloreen_US
dc.identifier.affiliationsDepartment of Pharmacology, Siddaganga Medical College and Research Institute, Tumkuren_US
dc.identifier.affiliationsDepartment of Medicine, Siddaganga Medical College and Research Institute, Tumkuren_US
dc.identifier.affiliationsDepartment of Biochemistry, Siddaganga Medical College and Research Institute, Tumkuren_US
dc.identifier.citationT I, S M, D P, Siddeswarswamy, D L.. Determination of Clinical and Radiological severity of COVID- 19 infection among vaccinated and non-vaccinated patients: A retrospective study in a tertiary care hospital . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Dec; 14(12): 2585-2590en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247835
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber12en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.5455/NJPPP.2024.v14.i12.15en_US
dc.subjectclinical severityen_US
dc.subjectCOVID-19en_US
dc.subjectpandemicen_US
dc.subjectradiological severityen_US
dc.subjectvaccinationen_US
dc.titleDetermination of Clinical and Radiological severity of COVID- 19 infection among vaccinated and non-vaccinated patients: A retrospective study in a tertiary care hospitalen_US
dc.typeJournal Articleen_US
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