Purification of rat intestinal cinnabarinate synthase and its possible role in hyperplasia of the small intestine in diabetic rats.

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dc.contributor.authorRajurkar, Ven_US
dc.contributor.authorPatil, Men_US
dc.contributor.authorShastri, N Ven_US
dc.date.accessioned1989-10-01en_US
dc.date.accessioned2009-05-27T09:07:18Z
dc.date.available1989-10-01en_US
dc.date.available2009-05-27T09:07:18Z
dc.date.issued1989-10-01en_US
dc.description.abstractStreptozotocin diabetic rats fed ad libitum exhibited hyperplasia of the small intestine. As compared to the control animals, the intestine of experimental animals grew in weight, length and total RNA and DNA contents. Intestinal cinnabarinate synthase activity in diabetic rats was however significantly lower. Developmental studies in albino rats indicated that, attainment of the terminal and highest activity of the enzyme tends to correspond with cessation of further increase in RNA and DNA contents of the intestine, thereby suggesting a possible relationship between cinnabarinate synthase and the hyperplastic changes observed. It was also observed that some properties of this enzyme, such as Km and Vmax are modified in diabetic condition. The enzyme was purified to apparent homogeneity and some of its kinetic and other properties were studied.en_US
dc.identifier.citationRajurkar V, Patil M, Shastri NV. Purification of rat intestinal cinnabarinate synthase and its possible role in hyperplasia of the small intestine in diabetic rats. Indian Journal of Biochemistry & Biophysics. 1989 Oct; 26(5): 334-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26516
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCatalase --isolation & purificationen_US
dc.subject.meshDiabetes Mellitus, Experimental --enzymologyen_US
dc.subject.meshHyperplasia --enzymologyen_US
dc.subject.meshIntestine, Small --enzymologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titlePurification of rat intestinal cinnabarinate synthase and its possible role in hyperplasia of the small intestine in diabetic rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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