Primary thyroid lymphoma: A series from a tertiary care center in Northern India

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dc.contributor.authorKakkar, Aanchalen_US
dc.contributor.authorPurkait, Suvenduen_US
dc.contributor.authorAgarwal, Shipraen_US
dc.contributor.authorMallick, Supriyaen_US
dc.contributor.authorGogia, Ajayen_US
dc.contributor.authorKarak, Asis Kumaren_US
dc.contributor.authorSharma, Mehar Chanden_US
dc.contributor.authorJulka, Pramod Kumaren_US
dc.date.accessioned2020-11-18T10:07:20Z
dc.date.available2020-11-18T10:07:20Z
dc.date.issued2019-05
dc.description.abstractObjective: Primary thyroid lymphoma (PTL) is a rare entity, necessitating accurate and early diagnosis, as its management is very different from that of other neoplasms intrinsic to the thyroid. Materials and Methods: Cases diagnosed between January 2009 and March 2015 were retrieved, and clinical details were noted. Hematoxylin- and eosin-stained slides were reviewed. Immunohistochemistry (IHC) was performed for immunophenotyping, and cases were classified according to the World Health Organization 2017 classification of hematolymphoid neoplasms. Results: Eleven patients with PTL were identified, with a mean age of 64.6 years (range: 40–76 years), including three males and eight females. Duration of symptoms ranged from 2 to 36 months (mean: 9.3 months). Diffuse large B-cell lymphoma (DLBCL) was most frequent, followed by extranodal marginal zone lymphoma. Most DLBCLs were nongerminal center type. BCL2 was positive in all DLBCLs. Strong p53 immunopositivity was not seen in any of the cases analyzed. Conclusion: Histopathological evaluation supplemented by IHC is the gold standard for the diagnosis of PTL. Combined chemoradiotherapy appears to be the best treatment modality, irrespective of histological type. MIB-1 and MUM1 IHC may have a role in identifying DLBCL, particularly in small biopsies. Role of p53 and BCL2 needs further evaluationen_US
dc.identifier.affiliationsDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Oncology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationKakkar Aanchal, Purkait Suvendu, Agarwal Shipra, Mallick Supriya, Gogia Ajay, Karak Asis Kumar, Sharma Mehar Chand, Julka Pramod Kumar. Primary thyroid lymphoma: A series from a tertiary care center in Northern India. Journal of Cancer Research and Therapeutics. 2019 May; 15(3): 669-675en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213403
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_135_17en_US
dc.subjectDiffuse large B‑cell lymphomaen_US
dc.subjectextranodalen_US
dc.subjectlymphomaen_US
dc.subjectMALT lymphomaen_US
dc.subjectmarginal zone lymphomaen_US
dc.titlePrimary thyroid lymphoma: A series from a tertiary care center in Northern Indiaen_US
dc.typeJournal Articleen_US
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