Effect of omeprazole on plasma zinc levels after oral zinc administration.

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dc.contributor.authorOzutemiz, A Omeren_US
dc.contributor.authorAydin, H Hakanen_US
dc.contributor.authorIsler, Mehmeten_US
dc.contributor.authorCelik, Handan Aken_US
dc.contributor.authorBatur, Yucelen_US
dc.date.accessioned2002-11-28en_US
dc.date.accessioned2009-05-29T03:08:34Z
dc.date.available2002-11-28en_US
dc.date.available2009-05-29T03:08:34Z
dc.date.issued2002-11-28en_US
dc.description.abstractBACKGROUND: The intestines are the major site of zinc absorption and excretion. Reduced gastric acid secretion and elevated gastric pH is an important factor affecting intestinal mineral absorption. METHODS: Gastric pH and volume, and basal and maximal acid outputs were measured in 14 healthy volunteers. Plasma zinc levels were then measured at baseline and 1, 2, 3 and 4 hours after oral administration of 300 mg zinc sulfate. The experiment was repeated after omeprazole administration (60 mg/day orally) for 7 days. RESULTS: Omeprazole administration significantly increased fasting gastric pH (5.5 versus 2.4; p < 0.001). Mean basal gastric acid output (1.6 vs 8.0 mEq/h; p < 0.001) and maximal acid output (20.6 vs 106.6 mEq/h; p < 0.001) decreased after omeprazole administration. Zinc absorption decreased after omeprazole administration (141 [34] mg/dL/h) compared with pre-omeprazole values (245 [35]; p < 0.01). CONCLUSION: Suppression of gastric acid secretion by omeprazole reduces intestinal absorption of zinc.en_US
dc.description.affiliationDepartment of Gastroenterology, Ege University School of Medicine, Bornova TR-35100, Izmir, Turkey. ozutemiz@med.ege.edu.tren_US
dc.identifier.citationOzutemiz AO, Aydin HH, Isler M, Celik HA, Batur Y. Effect of omeprazole on plasma zinc levels after oral zinc administration. Indian Journal of Gastroenterology. 2002 Nov-Dec; 21(6): 216-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64985
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAchlorhydria --blooden_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshArea Under Curveen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Acid --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshIntestinal Absorption --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshOmeprazole --pharmacologyen_US
dc.subject.meshZinc --administration & dosageen_US
dc.titleEffect of omeprazole on plasma zinc levels after oral zinc administration.en_US
dc.typeJournal Articleen_US
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