5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia.

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dc.contributor.authorSujitha, Subash Padmajeya
dc.contributor.authorNair, Asha
dc.contributor.authorBanerjee, Moinak
dc.contributor.authorLakshmanan, Srinivasan
dc.contributor.authorHarshavaradhan, Sampth
dc.contributor.authorGunasekaran, Soosiah
dc.contributor.authorGopinathan, Anil kumar
dc.date.accessioned2015-06-25T09:23:18Z
dc.date.available2015-06-25T09:23:18Z
dc.date.issued2014-12
dc.description.abstractBackground & objectives: Schizophrenia, the debilitating neuropsychiatric disorder, is known to be heritable, involving complex genetic mechanisms. Several chromosomal regions associated with schizophrenia have been identified during the past; putative gene (s) in question, to be called the global signature for the pathophysiology of the disease, however, seems to evade us. The results obtained from the several population-wise association-non association studies have been diverse. we therefore, undertook the present study on Tamil speaking population in south India to examine the association between the single nucleotide polymorphisms (SNPs) at the serotonin receptor gene (5HT2A) and the occurrence of the disease. Methods: Blood samples collected from 266 cases and 272 controls were subjected to genotyping (PCR amplification of candidate SNPs, RFLP and sequencing). The data on the SNPs were subjected to statistical analysis for assessing the gene frequencies in both the cases and the controls. Results: The study revealed significant association between the genotypic frequencies of the serotonin receptor polymorphism and schizophrenia. SNP analysis revealed that the frequencies of GG (30%, rs6311) and CC genotypes (32%, rs6313), were higher in patients (P<0.05) than in controls. The study also showed presence of G and C alleles in patients. significant levels of linkage disequilibrium (LD) were found to exist between the genotype frequencies of rs6311 and rs6313. Interpretation & conclusions: This study indicated an association between the SNPs (rs6311 and rs6313) of the serotonin receptor 5HT2A and schizophrenia. HapMap analysis revealed that in its genotype distribution, the Tamil speaking population was different from several other populations across the world, signifying the importance of such ethnicity-based studies to improve our understanding of this complex disease.en_US
dc.identifier.citationSujitha Subash Padmajeya, Nair Asha, Banerjee Moinak, Lakshmanan Srinivasan, Harshavaradhan Sampth, Gunasekaran Soosiah, Gopinathan Anilkumar. 5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia. Indian Journal of Medical Research. 2014 Dec; 140 (6): 736-743.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158369
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365347/?report=classicen_US
dc.subjectGC/CC homozygocityen_US
dc.subject5HT2A receptoren_US
dc.subjectlinkage disequilibriumen_US
dc.subjectrs6313en_US
dc.subjectschizophreniaen_US
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshGene Frequency
dc.subject.meshGenetic Association Studies
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshLinkage Disequilibrium
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshReceptor, Serotonin, 5-HT2A --genetics
dc.subject.meshSchizophrenia --genetics
dc.subject.meshSchizophrenia --pathology
dc.subject.meshSerotonin --genetics
dc.title5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia.en_US
dc.typeArticleen_US
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