Role of pleural fluid cholesterol in differentiating transudative from exudative pleural effusion.

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dc.contributor.authorGuleria, Ren_US
dc.contributor.authorAgarwal, S Ren_US
dc.contributor.authorSinha, Sanjeeven_US
dc.contributor.authorPande, J Nen_US
dc.contributor.authorMisra, Anoopen_US
dc.date.accessioned2003-03-21en_US
dc.date.accessioned2009-06-03T07:43:59Z
dc.date.available2003-03-21en_US
dc.date.available2009-06-03T07:43:59Z
dc.date.issued2003-03-21en_US
dc.description.abstractBACKGROUND: Pleural fluid cholesterol has been reported to be useful in distinguishing between transudative and exudative pleural effusion. However, the difference in lipid profile between tubercular and non-tubercular pleural effusion has not been studied. METHODS: The lipid profile of pleural fluid in 50 patients with exudative (25 tubercular and 25 non-tubercular) and 25 with transudative effusion was studied. The diagnosis was based on clinical criteria and/or a positive diagnosis from another site. RESULTS: The criteria that best identified an exudative pleural effusion were pleural fluid cholesterol > or = 60 mg/dl, pleural fluid to serum cholesterol ratio > or = 0.4, pleural fluid triglyceride > or = 40 mg/dl and pleural fluid to serum triglyceride ratio > or = 0.3. Pleural fluid cholesterol had a sensitivity of 88% and a specificity of 100% for exudates with an accuracy of 92%. Pleural fluid to serum cholesterol ratio had a sensitivity of 98% and a specificity of 84%. These results were superior to the criteria proposed by Light et al. (sensitivity 98% and specificity 80%). CONCLUSION: Pleural fluid cholesterol estimation is an effective and cost-efficient method of differentiating exudative from transudative pleural effusion. The lipid profile does not help in diagnosing tubercular effusion.en_US
dc.description.affiliationDepartment of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. randeepg@hotmail.comen_US
dc.identifier.citationGuleria R, Agarwal SR, Sinha S, Pande JN, Misra A. Role of pleural fluid cholesterol in differentiating transudative from exudative pleural effusion. National Medical Journal of India. 2003 Mar-Apr; 16(2): 64-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/119914
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdulten_US
dc.subject.meshCholesterol --analysisen_US
dc.subject.meshExudates and Transudatesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPleural Effusion --chemistryen_US
dc.subject.meshSensitivity and Specificityen_US
dc.titleRole of pleural fluid cholesterol in differentiating transudative from exudative pleural effusion.en_US
dc.typeJournal Articleen_US
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