Association between platelet aggregation parameters and primary open angle glaucoma

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dc.contributor.authorAgarwal, Ren_US
dc.contributor.authorSingh, Sen_US
dc.contributor.authorDhawan, Pen_US
dc.contributor.authorNarang, Aen_US
dc.contributor.authorGupta, Pen_US
dc.contributor.authorNamrataen_US
dc.contributor.authorKhan, S.en_US
dc.date.accessioned2025-05-12T07:25:30Z
dc.date.available2025-05-12T07:25:30Z
dc.date.issued2024-10
dc.description.abstractBackground: The aim of the research was to study association between platelet aggregation parameters and primary open angle glaucoma. Methods: An analytical cross sectional study with comparison group was conducted on 120 patients (60 cases, 60 controls). All enrolled patients underwent a comprehensive ophthalmological examination which included visual acuity assessment and refractive error testing, slit lamp examination, intraocular pressure (IOP) measurement with Goldmann's applanation tonometer, Gonioscopy using Sussman 4 mirror gonioscope, optic nerve head examination by slit lamp and biomicroscopy using +90D lens, visual field analysis and mean deviation assessment using automated perimeter in both eyes, retinal nerve fiber layer (RNFL) analysis by optical coherence tomography (OCT), complete blood count (CBC) analysis for the study of platelet aggregation parameters, platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT), mean platelet volume (MPV), and platelet large cell ratio (P-LCR). Results: Based on the direction of assessment, PCT was evaluated for prediction of glaucoma, a cut off of PCT <0.203 was found to be 83.3% sensitive and 53.3% specific. Severity of POAG did not show any significant association with any of the platelet aggregation parameters. Conclusions: In the present study, we did not find a significant association of different platelet parameters with severity of POAG either.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.citationAgarwal R, Singh S, Dhawan P, Narang A, Gupta P, Namrata, Khan S. . Association between platelet aggregation parameters and primary open angle glaucoma . International Journal of Research in Medical Sciences. 2024 Oct; 12(10): 3691-3697en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246848
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20242927en_US
dc.subjectPrimary open angle glaucomaen_US
dc.subjectPlatelet parameteren_US
dc.subjectVascular risk factorsen_US
dc.titleAssociation between platelet aggregation parameters and primary open angle glaucomaen_US
dc.typeJournal Articleen_US
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