Aggravating action of hydralazine on ethanol-induced gastric lesions.

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dc.contributor.authorBhandare, P Nen_US
dc.contributor.authorRataboli, P Ven_US
dc.contributor.authorDiniz D'Souza, R Sen_US
dc.contributor.authorDhume, V Gen_US
dc.date.accessioned1992-04-01en_US
dc.date.accessioned2009-06-01T07:49:23Z
dc.date.available1992-04-01en_US
dc.date.available2009-06-01T07:49:23Z
dc.date.issued1992-04-01en_US
dc.description.abstractEndogenous nitric oxide has been proposed as one of the mediators of gastric cytoprotection. We studied the effect of the vasodilator hydralazine which acts via nitric oxide and thus is expected to have a gastroprotective action. However, hydralazine aggravates ethanol-induced gastric lesions. This effect is not influenced by pretreatment with the selective alpha 1 adrenergic antagonist prazosin but is abolished by the angiotensin converting enzyme inhibitor, captopril suggesting the involvement of the renin-angiotensin system.en_US
dc.description.affiliationDepartment of Pharmacology, Goa Medical College, Tiswadi.en_US
dc.identifier.citationBhandare PN, Rataboli PV, Diniz D'Souza RS, Dhume VG. Aggravating action of hydralazine on ethanol-induced gastric lesions. Indian Journal of Physiology and Pharmacology. 1992 Apr; 36(2): 130-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108449
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCaptopril --pharmacologyen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEthanol --toxicityen_US
dc.subject.meshGastrointestinal Hemorrhage --chemically induceden_US
dc.subject.meshHydralazine --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshPrazosin --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshStomach --drug effectsen_US
dc.subject.meshStomach Diseases --chemically induceden_US
dc.titleAggravating action of hydralazine on ethanol-induced gastric lesions.en_US
dc.typeJournal Articleen_US
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