Is there an inter-organ glutathione redox cycle?

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dc.contributor.authorPunekar, N Sen_US
dc.date.accessioned1991-10-01en_US
dc.date.accessioned2009-05-27T09:28:21Z
dc.date.available1991-10-01en_US
dc.date.available2009-05-27T09:28:21Z
dc.date.issued1991-10-01en_US
dc.description.abstractIntracellular glutathione redox status is a function of the flux through glutathione peroxidase-glutathione reductase system. Specific activities of these two enzymes in rat liver cytosol and erythrocyte hemolysates were determined. Relative to glutathione peroxidase levels, glutathione reductase activity was about 15-fold more abundant in the rat liver than in erythrocytes. This is suggestive of greater capacity of the liver to reduce oxidised glutathione (GSSG). Based on these results and from the pattern of glutathione efflux from different cells and tissues [Sies, H. & Akerboom, T.P.M. (1984) Methods Enzymol. 105, 445-451], it is speculated that an interorgan glutathione redox cycle may be operative wherein liver is central to the reduction of GSSG and other disulphides.en_US
dc.description.affiliationChemistry Department, IIT, Bombay, India.en_US
dc.identifier.citationPunekar NS. Is there an inter-organ glutathione redox cycle? Indian Journal of Biochemistry & Biophysics. 1991 Oct-Dec; 28(5-6): 496-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27609
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshErythrocytes --metabolismen_US
dc.subject.meshGlutathione --metabolismen_US
dc.subject.meshLiver --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshOxidation-Reductionen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleIs there an inter-organ glutathione redox cycle?en_US
dc.typeJournal Articleen_US
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