Determination of Sample Size for Different Clinical Study Designs
No Thumbnail Available
Date
2024-07
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Indian Medical Association
Abstract
Aim: This study illustrates parameters, procedures, and calculations for the statistical determination of sample size for different clinical study designs. Materials and methods: In any research process, the sample size is an important consideration for the implementation of the planned study. From time to time, literature on sample size has been documented in the medical literature. However, the situations covered under them lack comprehensiveness in terms of different study designs, demonstration of calculations, and overreliance on statistical software. Results: The present study provides various facets of sample size determination, such as prerequisite parameters, mathematical formulation, and calculations for clinical study designs [descriptive studies, randomized controlled trials (RCT), correlational studies, comparison of multiple outcomes, survival analysis, sensitivity, and specificity], which will be quite useful. Conclusion: This communication will be a good education and learning source for medical professionals to pick and choose a specific scenario and estimate the sample size.
Description
Keywords
Citation
Verma Vivek, Mishra Ashwani Kumar, Narang Rajiv. Determination of Sample Size for Different Clinical Study Designs. Journal of the Association of Physicians of India. 2024 Jul; 72(7): 34–40