Gentamicin therapy in preterms: a comparison of two dosage regimens.

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dc.contributor.authorKrishnan, Len_US
dc.contributor.authorGeorge, S Aen_US
dc.date.accessioned1997-12-26en_US
dc.date.accessioned2009-05-27T06:00:03Z
dc.date.available1997-12-26en_US
dc.date.available2009-05-27T06:00:03Z
dc.date.issued1997-12-26en_US
dc.description.abstractOBJECTIVE: To compare the pharmacokinetic profile of gentamicin given as a once daily dose as against the conventional twelve hourly dose in preterm neonates. DESIGN: Randomized double blind study. SETTING: Tertiary level Neonatal Intensive Care Unit. SUBJECTS: Eighteen preterms admitted during the period January 1994 to May 1994. METHODS: The babies were randomly assigned to receive either the once daily (plan O, 4 mg/kg Q 24 h) or the conventional (plan C, 2.5 mg/kg Q 12 h) gentamicin dosage regimen. Blood was collected for the first peak level one hour after the first dose of gentamicin. Trough and peak-2 levels were collected before and one hour after the dose due at 48 hours, respectively. Assays were done using fluorescence immunoassay and the pharmacokinetic estimations were calculated using the three measured levels on a simplified one-compartment open model. Serum concentration time curves were plotted using the computerized Bayesian forecasting. Student 't' and Mann-Whitney U tests were applied as required. MAIN OUTCOME MEASURES: Initial peak levels and steady state trough and peak levels in both groups. RESULTS: Optimum therapeutic peak level after the first dose was achieved only with the once daily gentamicin regimen (mean level 5.88 vs 3.88 micrograms/ml p = 0.000). Mean trough levels remained over 2 micrograms/ml in the conventional regimen (2.76 vs 1.96 micrograms/ml p = 0.019) group. Mean peak levels at the steady state were not significantly different in either regimen (6.65 vs 5.45 micrograms/ml in conventional p = 0.177). None of the neonates showed nephrotoxicity. CONCLUSION: Once daily dose (4 mg/kg) of gentamicin has logistic and monetary benefits in addition to the obvious pharmacokinetic advantage.en_US
dc.description.affiliationDepartment of Pediatrics, Kasturba Medical College Hospital, Manipal.en_US
dc.identifier.citationKrishnan L, George SA. Gentamicin therapy in preterms: a comparison of two dosage regimens. Indian Pediatrics. 1997 Dec; 34(12): 1075-80en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/14376
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAnti-Bacterial Agents --administration & dosageen_US
dc.subject.meshBacterial Infections --prevention & controlen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshGentamicins --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInfant, Prematureen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshIntensive Care, Neonatalen_US
dc.subject.meshMaleen_US
dc.titleGentamicin therapy in preterms: a comparison of two dosage regimens.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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