Early Aggressive Enteral Feeding in Neonates Weighing 750-1250 Grams: A Randomized Controlled Trial

Simple item page
dc.contributor.authorModi, Manojen_US
dc.contributor.authorSiddarth, Ramjien_US
dc.contributor.authorJain, Ashishen_US
dc.contributor.authorKumar, Pradeepen_US
dc.contributor.authorGupta, Neerajen_US
dc.date.accessioned2020-04-23T07:43:56Z
dc.date.available2020-04-23T07:43:56Z
dc.date.issued2019-04
dc.description.abstractBackground: In preterm neonates, enteral feeding is advancedslowly, considering the risk of necrotizing enterocolitis. Prolongedintravenous alimentation in these neonates, however, mayincrease the risk of sepsis-related morbidity and mortality,particularly in low resource settings.Objectives: Objective of this was study to evaluate impact ofaggressive enteral feeding on mortality and morbidities amongpreterm neonates.Design: Randomized controlled trial.Participants: Neonates with birthweight 750-1250 g.Interventions: 131preterm neonates with birth weight 750-1250g, admitted to neonatal intensive care unit between April 2012 andJune 2014, were randomized to aggressive feeding orconservative feeding regimen.Outcomes: The primary outcome of the study was all-causemortality during hospital stay. The secondary outcomes includedproportion of sepsis (blood culture proven), necrotizingenterocolitis, feed intolerance, survival without major morbidity atdischarge, time to reach full enteral feed (180 mL/kg/d), durationof hospitalization, and average daily weight gain (g/kg).Results: All-cause mortality was 33.3% in aggressive regimenand 43.1% in conservative regimen, [RR (95%) CI 0.77 (0.49,1.20)]. Neonates with aggressive feeding regimen reached fullenteral feed earlier; median (IQR) 7 (6, 8) days compared toconservative regimen, 10 (9, 14) days; P <0.001. There was nodifference in culture positive sepsis rate, survival without majormorbidities, feed intolerance, necrotizing enterocolitis, duration ofhospitalization and average daily weight gain.Conclusions: In neonates with birth weight 750-1250 g, earlyaggressive feeding regimen is feasible but not associated withsignificant reduction in all-cause mortality, culture positive sepsisor survival without major morbidities during hospital stay.Neonates with aggressive regimen have fewer days on IV fluidsand reach full feed earlieren_US
dc.identifier.affiliationsDepartment of Pediatrics, Maulana Azad medical college, New Delhi, Indiaen_US
dc.identifier.citationModi Manoj, Siddarth Ramji, Jain Ashish, Kumar Pradeep, Gupta Neeraj. Early Aggressive Enteral Feeding in Neonates Weighing 750-1250 Grams: A Randomized Controlled Trial. Indian Pediatrics. 2019 Apr; 56(4): 294-298en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199305
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber4en_US
dc.relation.volume56en_US
dc.source.urihttps://www.indianpediatrics.net/apr2019/294.pdfen_US
dc.subjectEnteral feedingen_US
dc.subjectMorbidityen_US
dc.subjectMortalityen_US
dc.subjectNecrotizingenterocolitisen_US
dc.subjectPrematurityen_US
dc.subjectSepsisen_US
dc.titleEarly Aggressive Enteral Feeding in Neonates Weighing 750-1250 Grams: A Randomized Controlled Trialen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ip2019v56n4p294.pdf
Size:
31.52 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Pediatrics