Acquired immunodeficiency syndrome (AIDS) in multitransfused children with thalassemia.

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dc.contributor.authorSen, Sen_US
dc.contributor.authorMishra, N Men_US
dc.contributor.authorGiri, Ten_US
dc.contributor.authorPande, Ien_US
dc.contributor.authorKhare, S Den_US
dc.contributor.authorKumar, Aen_US
dc.contributor.authorChoudhry, V Pen_US
dc.contributor.authorChattopadhya, Den_US
dc.contributor.authorKumari, Sen_US
dc.contributor.authorMalaviya, A Nen_US
dc.date.accessioned1993-04-01en_US
dc.date.accessioned2009-05-27T05:13:49Z
dc.date.available1993-04-01en_US
dc.date.available2009-05-27T05:13:49Z
dc.date.issued1993-04-01en_US
dc.description.abstractTwo hundred and three multi-transfused children with thalassemia attending the Thalassemia Clinic of the Charak Palika Hospital, New Delhi were screened for human immunodeficiency virus (HIV) antibodies by ELISA and all positive cases were confirmed by Western Blot. Of the 203 children screened, 18 (8.9%) were HIV positive, and in these children a detailed immunological work up was done and compared to 18 age-matched HIV negative thalassemics as controls. The tests included absolute lymphocyte counts (ALC), absolute and percentages of CD4+ and CD8+ cells and their ratios (CD4/CD8), immunoglobulin levels (IgG, IgM and IgA) and delayed cutaneous hypersensitivity (DCH) test by Multitest CMI in all the cases and the controls. Of the 18 HIV positive children, 6 were diagnosed to have clinical AIDS as per the WHO criteria. After immunological testing, the children were further classified according to the CDC criteria. By these criteria, 11 children were classified as P1 A (asymptomatic infection, normal immune function), 1 child as P1 B (asymptomatic infection, abnormal immune function), 2 children as P2 A (symptomatic infection with non-specific findings), 1 child as P2 C (lymphocytic interstitial pneumonitis), 1 child as P2 D1 (Pneumocystis carinii pneumonia) and 2 children as P2 D2 (symptomatic infection with infections). In this paper, the clinical features of the children with AIDS is described, and the immunologic functions of these children are compared with the HIV positive asymptomatic children and with controls. These are the first cases of AIDS in the pediatric age group from India.en_US
dc.description.affiliationDepartment of Pediatrics, Charak Palika Hospital, Moti Bogh, New Delhi, India.en_US
dc.identifier.citationSen S, Mishra NM, Giri T, Pande I, Khare SD, Kumar A, Choudhry VP, Chattopadhya D, Kumari S, Malaviya AN. Acquired immunodeficiency syndrome (AIDS) in multitransfused children with thalassemia. Indian Pediatrics. 1993 Apr; 30(4): 455-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/9297
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAcquired Immunodeficiency Syndrome --etiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Transfusion --adverse effectsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Seropositivity --epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshThalassemia --therapyen_US
dc.subject.meshbeta-Thalassemia --therapyen_US
dc.titleAcquired immunodeficiency syndrome (AIDS) in multitransfused children with thalassemia.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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