Effect of cimetidine on adenohypophysis of male albino mice under certain experimental condition.

Simple item page
dc.contributor.authorChakraborty, Den_US
dc.date.accessioned1993-07-01en_US
dc.date.accessioned2009-06-01T06:28:32Z
dc.date.available1993-07-01en_US
dc.date.available2009-06-01T06:28:32Z
dc.date.issued1993-07-01en_US
dc.description.abstractEffect of 75 mg/kg of body weight of cimetidine administered intraperitoneally daily for 14 days to two groups of experimental animals (one of the experimental group was having intact testis and another group was bilaterally orchidectomized) was observed on cell population & cell volume of gonadotrophs and lactotrophs in pituitary gland, as it has not been studied earlier. In the experimental group of intact testis, there was significant reduction in the cell population of FSH cells in the cephalomedian area (P < 0.001) and in the lateral lobe (P < 0.01); the volume of both FSH and LH cells was also significantly reduced. In group 4 and group 5 there was significant increase in the population of lactotrophs and also in the volume of LH cells, FSH cells & lactotrophs. The change in the gonadotrophs in group 2 was due to increased production of testosterone from hypertrophied Leydig cells of testis rather then it's direct effect on adenohypophysis; in group 4 and group 5 the changes were due to lack of testosterone as in those cases bilaterally orchidectomy already done.en_US
dc.description.affiliationDepartment of Anatomy, Kasturba Medical College, Mangalore.en_US
dc.identifier.citationChakraborty D. Effect of cimetidine on adenohypophysis of male albino mice under certain experimental condition. Indian Journal of Physiology and Pharmacology. 1993 Jul; 37(3): 241-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107414
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCimetidine --pharmacologyen_US
dc.subject.meshFollicle Stimulating Hormone --biosynthesisen_US
dc.subject.meshLeydig Cells --drug effectsen_US
dc.subject.meshLuteinizing Hormone --biosynthesisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshOrchiectomyen_US
dc.subject.meshOrgan Size --drug effectsen_US
dc.subject.meshPituitary Gland, Anterior --cytologyen_US
dc.titleEffect of cimetidine on adenohypophysis of male albino mice under certain experimental condition.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Physiology and Pharmacology