Induction chemotherapy in technically unresectable locally advanced oral cavity cancers: Does it make a difference.

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dc.contributor.authorPatil, V M
dc.contributor.authorNoronha, V
dc.contributor.authorMuddu, V K
dc.contributor.authorGulia, S
dc.contributor.authorBhosale, B
dc.contributor.authorArya, S
dc.contributor.authorJuvekar, S
dc.contributor.authorChatturvedi, P
dc.contributor.authorChaukar, D A
dc.contributor.authorPai, P
dc.contributor.authorD'cruz, A
dc.contributor.authorPrabhash, K
dc.date.accessioned2013-07-17T10:03:03Z
dc.date.available2013-07-17T10:03:03Z
dc.date.issued2013-01
dc.description.abstractImpact Factor for 2013 is 1.131 Click here to download free Android Application for this and other journals Click here to view optimized website for mobile devices Journal is indexed with MEDLINE/Index Medicus and Science Citation Index ExpandedShare on facebookShare on twitterShare on citeulikeShare on connoteaShare on googleShare on linkedinMore Sharing Services MINI SYMPOSIUM: HEAD NECK CANCER Year : 2013 | Volume : 50 | Issue : 1 | Page : 1-8 Induction chemotherapy in technically unresectable locally advanced oral cavity cancers: Does it make a difference? VM Patil1, V Noronha1, VK Muddu1, S Gulia1, B Bhosale1, S Arya2, S Juvekar2, P Chatturvedi3, DA Chaukar3, P Pai3, A D'cruz3, K Prabhash1 1 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India 2 Department of Radio-Diagnosis, Tata Memorial Hospital, Mumbai, Maharashtra, India 3 Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India Date of Web Publication 20-May-2013 Correspondence Address: K Prabhash Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra India DOI: 10.4103/0019-509X.112263 PMID: 23713035 ยป Abstract Background: Locally advanced and unresectable oral cavity cancers have a poor prognosis. Induction might be beneficial in this setting by reducing tumor bulk and allowing definitive surgery. Aim: To analyze the impact of induction chemotherapy on locally advanced, technically unresectable oral cavity cancers. Materials and Methods: Retrospective analysis of patients with locally advanced oral cavity cancers, who were treated with neoadjuvant chemotherapy (NACT) during the period between June 2009 and December 2010. Data from a prospectively filled database were analyzed for information on patient characteristics, chemotherapy received, toxicity, response rates, local treatment offered, patterns of failure, and overall survival. The statistical analysis was performed with SPSS version 16. Results: 123 patients, with a median age of 42 years were analyzed. Buccal mucosa was the most common subsite (68.30%). Three drug regimen was utilized in 26 patients (21.10%) and the rest received two drug regimen. Resectability was achieved in 17 patients treated with 3 drug regimen (68.00%) and 36 patients receiving 2 drug regimen. Febrile neutropenia was seen in 3 patients (3.09%) receiving 2 drug regimen and in 9 patients (34.62%) receiving 3 drug regimen. The estimated median OS was not reached in patients who had clinical response and underwent surgery as opposed to 8 months in patients treated with non-surgical modality post NACT (P = 0.0001). Conclusion: Induction chemotherapy was effective in converting technically unresectable oral cavity cancers to operable disease in approximately 40% of patients and was associated with significantly improved overall survival in comparison to nonsurgical treatment.en_US
dc.identifier.citationPatil V M, Noronha V, Muddu V K, Gulia S, Bhosale B, Arya S, Juvekar S, Chatturvedi P, Chaukar D A, Pai P, D'cruz A, Prabhash K. Induction chemotherapy in technically unresectable locally advanced oral cavity cancers: Does it make a difference. Indian Journal of Cancer. 2013 Jan-Mar; 50(1): 1-8.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147312
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2013;volume=50;issue=1;spage=1;epage=8;aulast=Patilen_US
dc.subjectHead and neck neoplasmen_US
dc.subjectinduction chemotherapyen_US
dc.subjectlocally advanceden_US
dc.subjectoral cancersen_US
dc.subjectunresectableen_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic use
dc.subject.meshBridged Compounds --administration & dosage
dc.subject.meshBridged Compounds --adverse effects
dc.subject.meshFemale
dc.subject.meshFluorouracil --administration & dosage
dc.subject.meshFluorouracil --adverse effects
dc.subject.meshHumans
dc.subject.meshInduction Chemotherapy
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMouth Neoplasms --drug therapy
dc.subject.meshMouth Neoplasms --pathology
dc.subject.meshMouth Neoplasms --surgery
dc.subject.meshNeoadjuvant Therapy
dc.subject.meshNeutropenia --etiology
dc.subject.meshPlatinum --administration & dosage
dc.subject.meshPlatinum --adverse effects
dc.subject.meshRetrospective Studies
dc.subject.meshTaxoids --administration & dosage
dc.subject.meshTaxoids --adverse effects
dc.subject.meshYoung Adult
dc.subject.otherNeoplasm Staging
dc.subject.otherSurvival Analysis
dc.titleInduction chemotherapy in technically unresectable locally advanced oral cavity cancers: Does it make a difference.en_US
dc.typeArticleen_US
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