Surgical outcome of cortical dysplasias presenting with chronic intractable epilepsy: A 10-year experience.

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dc.contributor.authorTripathi, Manjarien_US
dc.contributor.authorSingh, Mahendra Sen_US
dc.contributor.authorPadma, M Ven_US
dc.contributor.authorGaikwad, Shaileshen_US
dc.contributor.authorBal, C Sen_US
dc.contributor.authorTripathi, Madhavien_US
dc.contributor.authorSarkar, Cen_US
dc.contributor.authorGupta, Adityaen_US
dc.contributor.authorShukla, Garimaen_US
dc.contributor.authorSingh, V Pen_US
dc.contributor.authorJain, Satishen_US
dc.contributor.authorSharma, Bhawani Sen_US
dc.contributor.authorChandra, P Saraten_US
dc.date.accessioned2008-04-09en_US
dc.date.accessioned2009-06-03T11:11:03Z
dc.date.available2008-04-09en_US
dc.date.available2009-06-03T11:11:03Z
dc.date.issued2008-04-09en_US
dc.description.abstractBackground: There has been sparse description of cortical dysplasias (CDs) causing intractable epilepsy from India. Aim: Clinical retrospective study of CDs causing intractable epilepsy that underwent surgery. Materials and Methods: Fifty-seven cases of CDs reviewed (1995 till July 2006) are presented. All patients had intractable epilepsy, and underwent a complete epilepsy surgery workup (inter ictal electroencephalography (EEG), video EEG, MRI as per epilepsy protocol, SPECT {interictal, ictal with subtraction and co-registration when required}, and PET when necessary). Surgical treatment included a wide exposure of the pathology with a detailed electrocorticography under optimal anesthetic conditions. Mapping of the sensori-motor area was performed where indicated. Procedures included resection either alone or combined with multiple subpial transactions when extending into the eloquent areas. Results: Our study had 28 (49.12%) cases of isolated focal CDs, and 29 (50.67%) with dual pathology. Average age at the time of onset of seizures in our series was 7.04 years (three months to 24 years), and average age at the time of surgery was 10.97 years (eight months to 45 years). Among coexistent pathologies, one had associated MTS, 16 had coexistent gangliogliomas and 12 (dysembryonic neuroepithelial tumor) DNTs. At an average follow-up of 3.035 years (range 5-10 years), three patients were lost to follow-up. Fifty-one per cent (29/57) patients had a good outcome (Engel Grade I) and 26%(15/57) had a Grade II outcome. Conclusion: Cortical dysplasias have a good outcome if evaluated and managed with concordant electrical and imaging modalities.en_US
dc.description.affiliationDepartment of Neurosurgery, All India Institute of Medical Sciences (AIIMS), New Delhi, India. saratpchandra@gmail.com.en_US
dc.identifier.citationTripathi M, Singh MS, Padma MV, Gaikwad S, Bal CS, Tripathi M, Sarkar C, Gupta A, Shukla G, Singh VP, Jain S, Sharma BS, Chandra PS. Surgical outcome of cortical dysplasias presenting with chronic intractable epilepsy: A 10-year experience. Neurology India. 2008 Apr-Jun; 56(2): 138-43en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/120720
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.titleSurgical outcome of cortical dysplasias presenting with chronic intractable epilepsy: A 10-year experience.en_US
dc.typeJournal Articleen_US
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