Hormonal influences on the oviducal lactate dehydrogenase and its isoenzymes.

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dc.contributor.authorVanithakumari, Gen_US
dc.contributor.authorGovindarajulu, Pen_US
dc.contributor.authorSrinivasan, Nen_US
dc.date.accessioned1980-10-01en_US
dc.date.accessioned2009-06-01T06:52:15Z
dc.date.available1980-10-01en_US
dc.date.available2009-06-01T06:52:15Z
dc.date.issued1980-10-01en_US
dc.description.abstractChanges in the specific activities and distribution of lactate dehydrogenase (LDH) isoenzymes have been studied in the oviduct of intact, ovariectomized and ovariectomized-hormone treated rats. Total LDH and M-subunits were higher in the oviduct during estrus compared to early diestrus phase. Ovariectomy lowered the total activity as well as the proportion of H and M-subunits of LDH, with a total loss of LDH. Treatment of ovariectomized rats with progesterone (2 mg/100 g. body wt/rat/day) and estradiol-17 beta (0.5 microgram/100 g body wt/rat/day) for 7 consecutive days induced marked augmentations in the total activities of this oviducal enzyme. Further, there was a shift in the isoenzyme patterns towards M-type, especially LDH5. Prolactin (400 microgram/100 g body wt/rat/day) depressed the total LDH activity and the distribution of isoenzymes. While LDH4 and LDH5 were very low, LDH1--LDH3, were inclusive, were absent in the oviduct of prolactin-treated group. None of the hormonal replacements could stimulate the LDH4 - subunit. The significance of these changes has been discussed in relation to metabolic activities in the tissue and hormonal influences.en_US
dc.identifier.citationVanithakumari G, Govindarajulu P, Srinivasan N. Hormonal influences on the oviducal lactate dehydrogenase and its isoenzymes. Indian Journal of Physiology and Pharmacology. 1980 Oct-Dec; 24(4): 335-40en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107719
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCastrationen_US
dc.subject.meshEstrusen_US
dc.subject.meshFallopian Tubes --enzymologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHormones --pharmacologyen_US
dc.subject.meshIsoenzymesen_US
dc.subject.meshL-Lactate Dehydrogenase --metabolismen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProlactin --pharmacologyen_US
dc.subject.meshRatsen_US
dc.titleHormonal influences on the oviducal lactate dehydrogenase and its isoenzymes.en_US
dc.typeJournal Articleen_US
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