Haemophilus influenzae type b vaccine in India: need and timing, immunogenecity and tolerance.

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dc.contributor.authorAcharya, Den_US
dc.contributor.authorBhave, Sen_US
dc.contributor.authorJoshi, Ven_US
dc.contributor.authorBavdekar, Aen_US
dc.contributor.authorPandit, Aen_US
dc.date.accessioned1997-01-01en_US
dc.date.accessioned2009-05-27T05:36:16Z
dc.date.available1997-01-01en_US
dc.date.available2009-05-27T05:36:16Z
dc.date.issued1997-01-01en_US
dc.description.abstractOBJECTIVE: (i) To assess the natural immunity and susceptibility to Haemophilus influenzae type b (Hib) infections in children in India. (ii) To study the immunogenecity and tolerance of Hib vaccine (ACTHIB) in young infants. DESIGNS: (i) Cross sectional study. (ii) Prospective trial. SETTING: Well baby and immunization clinics. METHODS: (i) PRP antibody titers against Hib estimated in 172 healthy infants and children aged 1 month to 10 years. (ii) Antibody titres estimated before and after ACTHIB vaccine given with primary immunization (age group 6 to 8 weeks) in 50 babies. RESULTS: (i) Naturally protective levels of Hib antibodies found in less than 20% of infants under one year, but in over 80% above 4 years. (ii) Seroconversion after ACTHIB vaccination was 100% with very high protective levels. There were no significant adverse reactions. CONCLUSIONS: ACTHIB vaccine proved to be safe and highly immunogenic. As susceptibility to Hib is highest in the first year of life, the vaccine should be recommended in the primary immunization schedule (combined with DPT). The very high titers achieved suggest the possibility of decreasing the number of doses or the amount of antigen to reduce the prevalent high cost.en_US
dc.description.affiliationDepartment of Pediatrics, K.E.M. Hospital, Pune.en_US
dc.identifier.citationAcharya D, Bhave S, Joshi V, Bavdekar A, Pandit A. Haemophilus influenzae type b vaccine in India: need and timing, immunogenecity and tolerance. Indian Pediatrics. 1997 Jan; 34(1): 9-15en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/11989
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDiphtheria-Tetanus-Pertussis Vaccine --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshHaemophilus Infections --immunologyen_US
dc.subject.meshHaemophilus Vaccines --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Innateen_US
dc.subject.meshImmunization Scheduleen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshVaccines, Combined --administration & dosageen_US
dc.titleHaemophilus influenzae type b vaccine in India: need and timing, immunogenecity and tolerance.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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