Intraoperative injection versus sponge-applied mitomycin C during trabeculectomy: One-year study

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dc.contributor.authorMaheshwari, Den_US
dc.contributor.authorKanduri, Sen_US
dc.contributor.authorRengappa, Ren_US
dc.contributor.authorKadar, MAen_US
dc.date.accessioned2020-04-10T02:07:32Z
dc.date.available2020-04-10T02:07:32Z
dc.date.issued2020-04
dc.description.abstractPurpose: To determine the safety and efficacy of mitomycin C (MMC) injection versus sponge during trabeculectomy. Methods: It is a prospective analysis of patients who underwent trabeculectomy with MMC and followed up for 1 year, divided into two groups, namely, group 1- injection (n = 21), group 2-> sponge (n = 21). The same concentration of MMC was used for both groups. Inclusion criteria were trabeculectomies with MMC for intraocular pressure (IOP) control in eyes with glaucoma (primary + secondary) with a follow-up of 1 year. Results: Mean preoperative IOP in group 1 was 29.00 � 11.92 mmHg and group 2 was 25.87 � 11.09 mmHg, which reduced to 12.19 � 4.03 and 15.56 � 10.72 mmHg at final visit with P value of 0.0002 and 0.001, respectively. Mean preoperative number of antiglaucoma medications was 2.4 � 0.87 in group 1 and 2.3 � 0.96 in group 2, which reduced to 0.38 � 0.5 and 0.91 � 0.85 with P value of 0.001 and 0.0003, respectively. The complete success rate was 52.4% in the injection group and 26.1% in the sponge group at end of 1 year. Overall, success rate (complete + qualified) was 90.5% and 87% in group 1 and group 2 at final visit. All major complications were encountered in sponge group. 1 (11.1%) patient developed choroidal detachment and one had malignant glaucoma which got resolved by medical management. 33.3% cases had encapsulated bleb which received bleb needling. 44.4% cases underwent Argon laser suture lysis postoperatively. Conclusion: The MMC injection may be as safe and as effective as conventional sponge application with comparable estimated complete treatment success.en_US
dc.identifier.affiliationsDepartment of Glaucoma, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu, Indiaen_US
dc.identifier.citationMaheshwari D, Kanduri S, Rengappa R, Kadar MA. Intraoperative injection versus sponge-applied mitomycin C during trabeculectomy: One-year study. Indian Journal of Ophthalmology. 2020 Apr; 68(4): 615-619en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/197871
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber4en_US
dc.relation.volume68en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_963_19en_US
dc.subjectInjectable mitomycin Cen_US
dc.subjectsponge soaked mitomycin Cen_US
dc.subjecttrabeculectomyen_US
dc.titleIntraoperative injection versus sponge-applied mitomycin C during trabeculectomy: One-year studyen_US
dc.typeJournal Articleen_US
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