Efficacy of Fixed Low Dose Hydroxyurea in Indian Children with Sickle Cell Anemia: A Single Centre Experience.
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Date
2013-10
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Abstract
Introduction: Data on the efficacy of hydroxyurea (HU) in Indian
children with sickle cell anaemia (SCA) is limited. Hence, we have
evaluated the efficacy of fixed low dose HU in Indian children.
Methods: The study cohort consisted of 144 children (<18
years of age) with SCA having severe manifestations (≥3
episodes of vasocclusive crisis or blood transfusions, or having
≥1 episode of acute chest syndrome or cerebrovascular stroke
or sequestration crisis) who were started on fixed low dose HU
(10 mg/kg/day). They were followed up for two years and
monitored for the hematological and clinical efficacy and safety.
Results: There was significant increase in the fetal hemoglobin
level (HbF%), total hemoglobin and mean corpuscular volume.
Vasoocclusive crises, blood transfusions, acute chest
syndrome, sequestration crises and hospitalizations decreased
significantly. Baseline HbF% had significant positive correlation
with HbF% at 24 months. There was significant negative
correlation between baseline HbF% and change in HbF% from
baseline to 24 months. No significant correlation was found
between HbF% at baseline and clinical event rates per year after
HU. No major adverse events occurred during the study period.
Conclusion: Fixed low dose HU is effective and safe in Indian
children with SCA.
Description
Keywords
Child, Hydroxyurea, India, Low dose, Sickle Cell disease
Citation
Jain Dipti L, Apte Mohini, Colah Roshan, Sarathi Vijaya, Desai Saumil, Gokhale Amruta, Bhandarwar Amol, Jain Harshwardhan L Ghosh Kanjaksha. Efficacy of Fixed Low Dose Hydroxyurea in Indian Children with Sickle Cell Anemia: A Single Centre Experience. Indian Pediatrics. 2013 October; 50(10): 929-933.