Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties

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dc.contributor.authorChan, Eric Wei Chiangen_US
dc.contributor.authorWong, Chen Waien_US
dc.contributor.authorYong, Hui Tanen_US
dc.contributor.authorFoo, Jenny Pei Yanen_US
dc.contributor.authorWong, Siu Kuinen_US
dc.contributor.authorChan, Hung Tucken_US
dc.date.accessioned2020-10-16T08:55:39Z
dc.date.available2020-10-16T08:55:39Z
dc.date.issued2019-07
dc.description.abstractBoth resveratrol and pterostilbene are monomeric stilbenes having a 6−2−6 carbon skeleton with two phenyl ringslinked by a double-bonded ethylene bridge. Resveratrol has three hydroxyl (−OH) groups, while pterostilbene hastwo methoxy (–OCH3) groups and one −OH group. They commonly occur in the trans form rather than the cis form.Red grapes and red wines are the main dietary sources of the resveratrol. Pterostilbene occurs in blueberries andgrapes. Resveratrol and pterostilbene exhibit many similarities in pharmacological properties, including antioxidant,neuroprotective anti-cancer, cardioprotective, analgesic, anti-atherosclerosis, anti-aging, anti-diabetic, antiinflammatory, and anti-obesity activities. The stronger pharmacological properties in pterostilbene than resveratrolhave been attributed to its two –OCH3 groups. As a result, pterostilbene is more lipophilic which enhances itsmembrane permeability, bioavailability, and biological potency. Some future studies on resveratrol and pterostilbeneare suggested. The sources of information cited in this comparative overview were from Science Direct, GoogleScholar, and PubMed.en_US
dc.identifier.affiliationsFaculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysiaen_US
dc.identifier.affiliationsFaculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.en_US
dc.identifier.affiliationsFaculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.en_US
dc.identifier.affiliationsFaculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.en_US
dc.identifier.affiliationsSchool of Science, Monash University Sunway, Selangor, Malaysia.en_US
dc.identifier.affiliationsSecretariat, International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa, Japanen_US
dc.identifier.citationChan Eric Wei Chiang, Wong Chen Wai, Yong Hui Tan, Foo Jenny Pei Yan, Wong Siu Kuin, Chan Hung Tuck. Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties. Journal of Applied Pharmaceutical Science. 2019 Jul; 2019 Jul: 124-129en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210414
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber7en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.90717en_US
dc.subjectResveratrolen_US
dc.subjectpterostilbeneen_US
dc.subjectpharmacologyen_US
dc.subjectpharmacokineticsen_US
dc.subjectfuture research.en_US
dc.titleResveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological propertiesen_US
dc.typeJournal Articleen_US
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