Medicinal Impact of Piper- Nigrum (Piperine) Against Arsenic Induced Hepatic and Renal Toxicity in Experimental Mice

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dc.contributor.authorSingh, Manish Kumaren_US
dc.contributor.authorKatiyar, Devendraen_US
dc.date.accessioned2020-01-02T06:08:25Z
dc.date.available2020-01-02T06:08:25Z
dc.date.issued2019-07
dc.description.abstractIn view of the increasing risk of arsenic on human health, the present study has been carried out to investigate the hepato-protective effect of piperine on arsenic induced-hepatic and renal toxicity in mice. Various oxidative stress parameter, antioxidant level and micro nutrients were analyses in hepatic and hepatic renal organ of mice. Methods: Mice exposed arsenic (sodium arsenate 5 mg/kg body weight p.o. for 45 days) caused a significant increases oxidative stress in hepatic and renal tissue as compared to controls group. Results: Abnormal levels of arsenic in hepatic and renal tissue increased the levels of ROS, LPO, and decreased the levels of GSH with SOD, CAT, and GPx activities in the hepatic and renal tissue of mice as compared to controls. Co-treatment of arsenic with piperine (1.5 mg/kg body weight p.o. for 45 days) decreased the levels of ROS, LPO, and increased the level of GSH, also increased SOD, CAT, and GPx activity and showed improvements in hepatic and renal tissue of mice as compared to arsenic-treated groups. Conclusion: Our results proved that piperine worked as antioxidant, anti- inflammatory in nature.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Government Medical College Badaun - 243601 (UP), India.en_US
dc.identifier.affiliationsDepartment of Pharmacology, King George Medical University, Lucknow - 226 003 (UP), India.en_US
dc.identifier.citationSingh Manish Kumar, Katiyar Devendra. To Assess Risk Factors of Chronic Diseases in Geriatrics. Annals of International medical and Dental Research. 2019 Jul; 5(4): 1-7en_US
dc.identifier.issn2395-2822
dc.identifier.issn2395-2814
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188919
dc.languageenen_US
dc.publisherSociety for Health Care & Research Developmenten_US
dc.relation.issuenumber4en_US
dc.relation.volume5en_US
dc.source.urihttps://doi.org/10.21276/aimdr.2019.5.4.BC1en_US
dc.subjectHepatic toxicityen_US
dc.subjectrenal toxicityen_US
dc.subjectPiperineen_US
dc.titleMedicinal Impact of Piper- Nigrum (Piperine) Against Arsenic Induced Hepatic and Renal Toxicity in Experimental Miceen_US
dc.typeJournal Articleen_US
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