Pharmaceutical Care in Patients with Side Effects to Oral Antineoplastic Agents: A Case Report

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dc.contributor.authorAlarcon, TCen_US
dc.contributor.authorMuñoz-Cejudo, BMen_US
dc.contributor.authorMora-Mora, MA.en_US
dc.date.accessioned2025-05-12T10:22:29Z
dc.date.available2025-05-12T10:22:29Z
dc.date.issued2024-12
dc.description.abstractBackground: Chronic myeloid leukaemia (CML) is a haematopoietic stem cell disease characterised by the proliferation of granulocytes and their immature myeloid precursors. The treatments recommended are oral treatments dispensed in the outpatient unit (OU) of the hospital’s pharmacy service (PS), where patient-centred pharmaceutical care (PC) is essential to enhance therapeutic adherence, detect drug interactions and create a pharmacist-patient relationship to educate the patient on the main potential toxicities derived from the treatment and warning signs or symptoms requiring immediate attention. Methodology: We present the case of a 55-year-old woman, followed up in consultation by the Haematology Service (HS) since October 2021 for CML in the chronic phase. Results: She started treatment on nilotinib 300 mg every 12 hours. The patient attended OU and was offered PC. After 12 months, nilotinib was well tolerated, but our patient experienced a loss of effectiveness, so HS decided to switch to dasatinib 100 mg daily. After one year of treatment, our patient was presented with symptoms of swelling and dyspnoea on moderate exertion. In January 2024, following a joint Haematology-Pharmacy session, a switch to bosutinib 400 mg daily was decided. After 15 days of treatment, the patient presented without an appointment due to a pruritic generalised rash on the torso, face, and extremities, being diagnosed with leukocytoclastic vasculitis. Conclusion: In conclusion, we describe case reports of a patient who has a lack of effectiveness and ARs in several TKIs and the importance of identifying side effects, through early and close PC, in order for the patient’s evolution to be favourable.en_US
dc.identifier.affiliationsDepartment of Pharmacy Service, Hospital San Agustín de Linares (Jaén), Linares, Jaén, Spainen_US
dc.identifier.affiliationsDepartment of Pharmacy Service, Hospital San Agustín de Linares (Jaén), Linares, Jaén, Spainen_US
dc.identifier.affiliationsDepartment of Pharmacy Service, Hospital San Agustín de Linares (Jaén), Linares, Jaén, Spainen_US
dc.identifier.citationAlarcon TC, Muñoz-Cejudo BM, Mora-Mora MA.. Pharmaceutical Care in Patients with Side Effects to Oral Antineoplastic Agents: A Case Report. Journal of Pharmacology and Pharmacotherapeutics. 2024 Dec; 15(4): 427-430en_US
dc.identifier.issn0976-500X
dc.identifier.issn0976-5018
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247674
dc.languageenen_US
dc.publisherSage Publications India Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.1177/0976500X241283125en_US
dc.subjectAllergic reactionsen_US
dc.subjectpharmacologyen_US
dc.subjectpharmacotherapeuticsen_US
dc.subjectlocal-level communitiesen_US
dc.titlePharmaceutical Care in Patients with Side Effects to Oral Antineoplastic Agents: A Case Reporten_US
dc.typeJournal Articleen_US
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