Influence of acetylator phenotype of the leprosy patient on the emergence of dapsone resistant leprosy.

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dc.contributor.authorRaj, P Pen_US
dc.contributor.authorAschhoff, Men_US
dc.contributor.authorLilly, Len_US
dc.contributor.authorBalakrishnan, Sen_US
dc.date.accessioned1988-07-01en_US
dc.date.accessioned2009-05-28T10:12:43Z
dc.date.available1988-07-01en_US
dc.date.available2009-05-28T10:12:43Z
dc.date.issued1988-07-01en_US
dc.description.abstractThe half time of disappearance of dapsone and monoacetyl dapsone and the acetylator phenotype of the leprosy patients who harboured dapsone sensitive and dapsone resistant M. leprae was assessed in 27 subjects. Sixteen patients were rapid acetylators, five were slow and six were intermediate acetylators. The mean T 1 1/2 lives of dapsone (30.26 +/- 11.0) and monoacetyl dapsone (31.11 +/- 12.0) were also studied in the above patients. The percentage of different acetylators in both resistant and sensitive groups were similar showing no correlation between the emergence of drug resistance and the phenotype of the patient. The mean time of disappearance of DDS and MAD in the different acetylators did not show significant difference. The ratios of MAD/DDS in an individual at 3, 6 or 24 hours after the dose were similar. The mean T 1 1/2 lives of DDS and MAD in resistant and sensitive patients also showed no difference. Neither T 1 1/2 lives of DDS or MAD nor the acetylator phenotype seem to influence the emergence of dapsone resistance.en_US
dc.description.affiliationSt. Thomas Hospital and Leprosy Centre, Chettupattu, Tamil Nadu.en_US
dc.identifier.citationRaj PP, Aschhoff M, Lilly L, Balakrishnan S. Influence of acetylator phenotype of the leprosy patient on the emergence of dapsone resistant leprosy. Indian Journal of Leprosy. 1988 Jul; 60(3): 400-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55007
dc.language.isoengen_US
dc.subject.meshAcetylationen_US
dc.subject.meshDapsone --analogs & derivativesen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHalf-Lifeen_US
dc.subject.meshHumansen_US
dc.subject.meshLeprosy --geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMycobacterium leprae --drug effectsen_US
dc.subject.meshPhenotypeen_US
dc.titleInfluence of acetylator phenotype of the leprosy patient on the emergence of dapsone resistant leprosy.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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