A trial of deferiprone in transfusion-dependent iron overloaded children.

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dc.contributor.authorLucas, G Nen_US
dc.contributor.authorPerera, B Jen_US
dc.contributor.authorFonseka, E Aen_US
dc.contributor.authorDe Silva, D Den_US
dc.contributor.authorFernandopulle, Men_US
dc.date.accessioned2009-05-28T05:55:15Z
dc.date.available2009-05-28T05:55:15Z
dc.date.issued2000-06-29en_US
dc.descriptionThe Ceylon Medical Journal.en_US
dc.description.abstractOBJECTIVE: To determine the efficacy and safety of deferiprone. DESIGN: Prospective study. SETTING: 5 paediatric medical units at the Lady Ridgeway Hospital for Children (LRHC), Colombo. PATIENTS: Transfusion-dependent iron overloaded children in the age group 2 to 15 years. INTERVENTION: Patients were given a total daily dose of 75 mg/kg of deferiprone orally in divided doses. MEASUREMENTS: Efficacy of deferiprone therapy was assessed by 4-monthly serum ferritin assays using the ELISA technique. Safety of deferiprone therapy was assessed by 4-weekly white cell counts, platelet counts and serum transaminase levels. The Z-test was used to assess the significance of the difference between the mean initial serum ferritin level and the mean subsequent serum ferritin level. RESULTS: 54 patients received deferiprone therapy for a mean duration of 9 +/- 3 months. Initial serum ferritin levels ranged from 1500 to 10,700 ng/ml with a mean of 5743. Subsequent serum ferritin levels, obtained in 48 patients ranged from 740 to 7300 ng/ml with a mean of 3558 (p < 0.001). In 47 of the 48 patients subsequent serum ferritin levels were lower than initial levels. One child developed severe neutropaenia, which reverted to normal on discontinuation of treatment. 11 children developed arthropathy, which responded to ibuprofen therapy combined in some cases with a reduction of the dose of deferiprone to 50 mg/kg/day. Serum transaminase levels were raised in 5 patients but reverted to pretreatment values or lower despite continuation of deferiprone therapy. CONCLUSIONS: Deferiprone is a safe and effective oral iron-chelating agent which can be used, under strict supervision, in transfusion-dependent iron overloaded children.en_US
dc.description.affiliationLady Ridgeway Hospital for Children, Colombo.en_US
dc.identifier.citationLucas GN, Perera BJ, Fonseka EA, De Silva DD, Fernandopulle M. A trial of deferiprone in transfusion-dependent iron overloaded children. The Ceylon Medical Journal. 2000 Jun; 45(2): 71-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/49250
dc.language.isoengen_US
dc.source.urihttps://www.infolanka.com/CMJhome/en_US
dc.subject.meshAdolescenten_US
dc.subject.meshBlood Transfusion --adverse effectsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFerritins --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIron Chelating Agents --administration & dosageen_US
dc.subject.meshIron Overload --drug therapyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshPyridones --administration & dosageen_US
dc.subject.meshSri Lankaen_US
dc.subject.meshbeta-Thalassemia --therapyen_US
dc.titleA trial of deferiprone in transfusion-dependent iron overloaded children.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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