Interpretation of hemoglobin analysis for diagnosis of common thalassemia in Thailand
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2009-12-24
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Khon Kaen University
Abstract
At present hemoglobin (Hb) analysis is mainly performed using automated hemoglobin analyzer based on eitherhigh pressure liquid chromatography (HPLC), low pressure liquid chromatography (LPLC) or capillary zoneelectrophoresis (CZE). These automated Hb analyzers separate each Hb and quantify its amount by builtin spectrophotometric determination. Hb chromatogram or electrophoregram as well as the amount of each Hbare shown and could be printed. Interpretation of the result of Hb analysis is usually made by investigator whoperforms the test. Accurate interpretation and diagnosis require basic knowledge on both the principle ofthe machine used and the heterogeneity of thalassemia which is the most common inherited genetic disorderin Thailand. Using subject information including age, clinically signs and symptoms, history of blood transfusionand the result of initial screening test in this interpretation and diagnosis should help in providing more accurateinterpretation and diagnosis of common forms of thalassemia.
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Journal of Medical Technology and Physical Therapy; Volume 21 Number 3, September - December 2009; 212-225