Misoprostol in the treatment of NSAID-induced gastroduodenal lesions.

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dc.contributor.authorAhmed, W Uen_US
dc.contributor.authorKirmani, S Ren_US
dc.contributor.authorQureshi, Hen_US
dc.contributor.authorAlam, S Een_US
dc.contributor.authorZuberi, S Jen_US
dc.date.accessioned1991-10-01en_US
dc.date.accessioned2009-05-29T02:30:18Z
dc.date.available1991-10-01en_US
dc.date.available2009-05-29T02:30:18Z
dc.date.issued1991-10-01en_US
dc.description.abstractThe cytoprotective effect of misoprostol co-administered with non-steroidal anti-inflammatory drugs (NSAIDs) was assessed in a double blind, placebo controlled study. Thirty-seven patients with rheumatoid arthritis receiving NSAIDs, having upper gastrointestinal symptoms and endoscopically confirmed gastric and/or duodenal lesions, were randomised to receive either misoprostol 200 micrograms or placebo tablets twice daily for 4 weeks. Of 31 evaluable cases, 13 of 16 (81%) patients receiving misoprostol showed endoscopic improvement as compared to 10 of 15 (67%) receiving placebo (P:NS). A significant decrease in mean (+/- SEM) mucosal lesion score was observed with misoprostol (from 3.38 +/- 0.32 to 1.32 +/- 0.44; P less than 0.001) but no change was seen with placebo (from 2.80 +/- 0.42 to 1.60 +/- 0.53; P:NS). Symptomatic relief was similar in both groups, being 44% and 40% respectively. Two patients complained of diarrhea in each group and one developed menorrhagia with misoprostol. It is concluded that though misoprostol decreased the number of NSAID-induced mucosal lesions, it was unable to relieve gastrointestinal symptoms.en_US
dc.description.affiliationResearch Centre, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.en_US
dc.identifier.citationAhmed WU, Kirmani SR, Qureshi H, Alam SE, Zuberi SJ. Misoprostol in the treatment of NSAID-induced gastroduodenal lesions. Indian Journal of Gastroenterology. 1991 Oct; 10(4): 135-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64222
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --adverse effectsen_US
dc.subject.meshArthritis, Rheumatoid --drug therapyen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Diseases --chemically induceden_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMisoprostol --therapeutic useen_US
dc.titleMisoprostol in the treatment of NSAID-induced gastroduodenal lesions.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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