Differences in vancomycin MIC among MRSA isolates by agar dilution and E test method.

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dc.contributor.authorTandel, K
dc.contributor.authorPraharaj, A K
dc.contributor.authorKumar, S
dc.date.accessioned2012-12-20T10:32:35Z
dc.date.available2012-12-20T10:32:35Z
dc.date.issued2012-10
dc.description.abstractIn this study, the correlation between vancomycin minimum inhibitory concentration (MIC) obtained by the E test technique and the Clinical And Laboratory Standards Institute (CLSI) agar dilution method was evaluated. A total of 53 Methicillin Resistant Staphylococcus aureus (MRSA) strains were tested by both the methods in the present study. MICs of vancomycin obtained by the E test method were consistently higher (+0.5 to 2 log2 dilutions) than those obtained by the agar dilution method. Out of 53 MRSA isolates, 49 isolates showed higher MIC results by E test than by agar dilution method. Three isolates showed same MIC result by both methods. Since many studies have demonstrated increased clinical failure with MRSA isolates for which vancomycin MICs are increased (>1 μg/ml) but still within the susceptibility range (≤ 2 μg/ml), our findings suggest the requirement to re-look into the breakpoints for vancomycin for determining sensitivity of MRSA isolates. Guidelines should also specify the method to be used for determining the MIC.en_US
dc.identifier.citationTandel K, Praharaj A K, Kumar S. Differences in vancomycin MIC among MRSA isolates by agar dilution and E test method. Indian Journal of Medical Microbiology. 2012 Oct-Dec; 30(4): 453-455.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144009
dc.language.isoenen_US
dc.source.urihttps://www.ijmm.org/article.asp?issn=0255-0857;year=2012;volume=30;issue=4;spage=453;epage=455;aulast=Tandelen_US
dc.subjectMethicillin Resistant Staphylococcus aureusen_US
dc.subjectvancomycinen_US
dc.subjectStaphylococcus aureusen_US
dc.subject.meshAgar
dc.subject.meshMethicillin-Resistant Staphylococcus aureus --drug effects
dc.subject.meshMethicillin-Resistant Staphylococcus aureus --isolation & purification
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshSensitivity and Specificity
dc.subject.meshVancomycin --pharmacology
dc.subject.meshVancomycin --therapeutic use
dc.titleDifferences in vancomycin MIC among MRSA isolates by agar dilution and E test method.en_US
dc.typeArticleen_US
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