Oxidative stress and antioxidant status in cancer patients and healthy subjects, a case-control study.

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dc.contributor.authorAdhikari, Deepaken_US
dc.contributor.authorBaxi, Jalajen_US
dc.contributor.authorRisal, Sanjiven_US
dc.contributor.authorSingh, Prem Prakashen_US
dc.date.accessioned2009-05-28T04:24:34Z
dc.date.available2009-05-28T04:24:34Z
dc.date.issued2005-12-08en_US
dc.descriptionNepal Medical College Journal.en_US
dc.description.abstractSince raised oxidative stress (OS) or weak antioxidant defence or both are considered to be important players in multimechanistic pathogenesis of cancer, the present study was undertaken to evaluate their possible involvement in the pathogenesis of this disease in the local population. Levels of plasma vitamin C, vitamin E, total antioxidant activity (TAA) and thiobarbituric acid reacting substances (TBARS) as a marker of OS were measured in 20 cancer patients (Mean age 63.1 + 9.3 yr.) and 20 age, sex and socioeconomically matched healthy subjects (Mean age 63.7+7.8 yr.). Significantly low level of vitamin C (p <0.001), vitamin E (p <0.001) and TAA (p <0.003) were observed in cancer patients, whereas OS was significantly increased in patients as compared to control (p <0.003). Smokers had significantly lowered TAA and significantly raised OS than non-smokers, in both case and control groups. Tobacco chewer patients had raised OS as compared to control. This study supports the thesis that OS is a risk factor in carcinogenesis and that smoking, an established risk factor in cancer, at least partly appears through it.en_US
dc.description.affiliationDepartment of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal. deepakadhikari@rediffmail.comen_US
dc.identifier.citationAdhikari D, Baxi J, Risal S, Singh PP. Oxidative stress and antioxidant status in cancer patients and healthy subjects, a case-control study. Nepal Medical College Journal. 2005 Dec; 7(2): 112-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/46901
dc.language.isoengen_US
dc.source.urihttps://www.nmcth.edu/list_journal_articles.phpen_US
dc.subject.meshAgeden_US
dc.subject.meshAscorbic Acid --blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasms --blooden_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThiobarbiturates --blooden_US
dc.subject.meshVitamin E --blooden_US
dc.titleOxidative stress and antioxidant status in cancer patients and healthy subjects, a case-control study.en_US
dc.typeJournal Articleen_US
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