Carcinoid Syndrome-induced Multi-valvular Heart Disease: A Rare Cause of Heart Failure in a 45-Year-Old Woman

Simple item page
dc.contributor.authorAlaa, ATen_US
dc.contributor.authorSaleh, Oen_US
dc.contributor.authorSamia, Een_US
dc.contributor.authorMERYEM, Aen_US
dc.contributor.authorMeryem, Hen_US
dc.contributor.authorRachida, H.en_US
dc.date.accessioned2025-08-13T10:11:29Z
dc.date.available2025-08-13T10:11:29Z
dc.date.issued2025-06
dc.description.abstractBackground: Carcinoid syndrome, a rare neuroendocrine disorder, can lead to progressive valvular fibrosis due to the excessive secretion of serotonin and other vasoactive substances. This typically affects the right-sided cardiac valves and rarely the left side. The resulting carcinoid heart disease represents an uncommon but serious cause of heart failure. Presentation of Case: We report the case of a 45-year-old woman admitted for progressive heart failure symptoms, including dyspnea, peripheral edema, and fatigue. She also experienced flushing and diarrhea suggestive of carcinoid syndrome. Transthoracic echocardiography revealed severe tricuspid, mitral, and aortic valve involvement, with biatrial dilation and features of severe stenosis and regurgitation. Work-up revealed elevated urinary 5-HIAA and chromogranin A levels, and imaging identified a hyper vascular ileocecal mass consistent with a neuroendocrine tumor. The diagnosis of carcinoid syndrome with multivalvular carcinoid heart disease was established. Discussion: This case illustrates the diagnostic challenge of distinguishing carcinoid heart disease from other etiologies such as rheumatic heart disease. The rare left-sided valvular involvement, likely due to high circulating serotonin levels, underscores the severity of tumor burden. Early identification through echocardiography and biochemical markers is crucial. Management requires both symptomatic treatment of heart failure and control of the underlying tumor through somatostatin analogs and surgical or oncologic intervention. Conclusion: Carcinoid-induced multivalvular heart disease is a rare but critical diagnosis in patients with neuroendocrine tumors. Optimal care requires a multidisciplinary approach combining cardiology, oncology, and cardiac surgery to improve outcomes and manage complex systemic involvement.en_US
dc.identifier.affiliationsDepartment of Cardiology, University Hospital IBN ROCHD, Casablanca, Moroccoen_US
dc.identifier.affiliationsDepartment of Cardiology, University Hospital IBN ROCHD, Casablanca, Moroccoen_US
dc.identifier.affiliationsDepartment of Cardiology, University Hospital IBN ROCHD, Casablanca, Moroccoen_US
dc.identifier.affiliationsDepartment of Cardiology, University Hospital IBN ROCHD, Casablanca, Moroccoen_US
dc.identifier.affiliationsDepartment of Cardiology, University Hospital IBN ROCHD, Casablanca, Moroccoen_US
dc.identifier.affiliationsDepartment of Cardiology, University Hospital IBN ROCHD, Casablanca, Morocco.en_US
dc.identifier.citationAlaa AT, Saleh O, Samia E, MERYEM A, Meryem H, Rachida H.. Carcinoid Syndrome-induced Multi-valvular Heart Disease: A Rare Cause of Heart Failure in a 45-Year-Old Woman . Cardiology and Angiology: An International Journal. 2025 Jun; 14(2): 17-23en_US
dc.identifier.issn2347-520X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253169
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber2en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.9734/ca/2025/v14i2483en_US
dc.subjectCarcinoid heart diseaseen_US
dc.subjectmulti-valvular diseaseen_US
dc.subjectserotonin-induced fibrosisen_US
dc.subjectcase reporten_US
dc.titleCarcinoid Syndrome-induced Multi-valvular Heart Disease: A Rare Cause of Heart Failure in a 45-Year-Old Womanen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
caij2025v14n2p17.pdf
Size:
481.88 KB
Format:
Adobe Portable Document Format
Download
Collections
Cardiology and Angiology: An International Journal