Diethylcarbamazine: inhibitory effect on acetylcholinesterase of Dirofilaria immitis and Brugia pahangi.

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dc.contributor.authorFujimaki, Yen_US
dc.contributor.authorSakamoto, Men_US
dc.contributor.authorShimada, Men_US
dc.contributor.authorKimura, Een_US
dc.contributor.authorAoki, Yen_US
dc.date.accessioned2009-05-27T16:53:45Z
dc.date.available2009-05-27T16:53:45Z
dc.date.issued1989-06-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractAnti-acetylcholinesterase activity of diethylcarbamazine (DEC) was studied. Acethylcholinesterase (AchE) of adult worms of Dirofilaria immitis, those of the 4th-stage larvae, early 5th-stage larvae and adults worms of Brugia pahangi, and that of hamster brain tissue were all inhibited by DEC. Michaelis constant (Km) of D. immitis and B. pahangi adult worm AchE were 1.47 x 10(-4) and 1.81 x 10(-4) M respectively. DEC was a competitive inhibitor of the filarial AchE. Inhibition constant (Ki) for AchE of D. immitis and B. pahangi adult worms were 2.56 x 10(-4) and 6.39 x 10(-4) M, respectively. DEC is a less potent anticholinesterase inhibitor, because Ki of DEC is 10(4) times higher than that of eserine, a potent anti-cholinesterase agent.en_US
dc.description.affiliationDepartment of Parasitology, Nagasaki University, Japan.en_US
dc.identifier.citationFujimaki Y, Sakamoto M, Shimada M, Kimura E, Aoki Y. Diethylcarbamazine: inhibitory effect on acetylcholinesterase of Dirofilaria immitis and Brugia pahangi. The Southeast Asian Journal of Tropical Medicine and Public Health. 1989 Jun; 20(2): 179-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36253
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAcetylcholinesterase --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain --enzymologyen_US
dc.subject.meshBrugia --enzymologyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDiethylcarbamazine --pharmacologyen_US
dc.subject.meshDirofilaria immitis --enzymologyen_US
dc.subject.meshFilarioidea --enzymologyen_US
dc.subject.meshLarva --enzymologyen_US
dc.titleDiethylcarbamazine: inhibitory effect on acetylcholinesterase of Dirofilaria immitis and Brugia pahangi.en_US
dc.typeJournal Articleen_US
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