The prognostic values of the IL?10 (G1082A) and TNF?? (G308A) polymorphisms in Egyptian patients with acute lymphoblastic leukemia: A single?center study

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dc.contributor.authorBaiomy, Mohamed A. Elen_US
dc.contributor.authorAkl, Tameren_US
dc.contributor.authorEl-Menshawy, Nadiaen_US
dc.contributor.authorEl?Sebaie, Ahmed H.en_US
dc.contributor.authorMorkos, Hannaen_US
dc.contributor.authorEl?Ashwah, Shaimaaen_US
dc.contributor.authorEl?Sabbagh, Amr M.en_US
dc.contributor.authorWahba, Yahyaen_US
dc.contributor.authorEl?Ghonemy, Mohameden_US
dc.date.accessioned2023-08-09T06:04:29Z
dc.date.available2023-08-09T06:04:29Z
dc.date.issued2023-06
dc.description.abstractBackground: Interleukin?10 (IL?10) and tumor necrosis factor?alpha (TNF??) genes contribute to oncogenesis. We evaluated the influence of the IL?10 (G1082A) and TNF?? (G308A) polymorphisms on the prognosis and outcomes of Egyptian patients with acute lymphoblastic leukemia (ALL). Materials and Methods: We investigated 64 children and 76 adults with ALL, between 2016 and 2019, for the IL?10 (G1082A) and TNF?? (G308A) polymorphisms using allele?specific polymerase chain reaction and polymerase chain reaction杛estriction fragment length polymorphism. Survival analyses were performed using the Kaplan朚eier estimator and the log?rank test. Results: In children with ALL, the A allele of TNF?? and IL?10 polymorphisms was associated with older age (P = 0.04 and 0.03), more extramedullary disease (P = 0.02 and 0.001), positive breakpoint cluster region朅belson (BCR?ABL) rearrangement (p190; P = 0.04 and 0.001), and more relapse (P = 0.002). The IL?10 GG genotype was associated with higher overall survival in children (P = 0.026). Adults carrying the TNF?? A allele showed more extramedullary disease (P = 0.009) and relapse (P = 0.003). We also found a higher frequency of IL?10 A allele in adults with older age (P = 0.03), lower hemoglobin level (P = 0.04), positive BCR?ABL rearrangement (P = 0.001), more extramedullary disease (P = 0.001), more relapse (P = 0.002), and a longer time for the first complete remission (P = 0.003). Conclusion: A possible association exists between the A allele of IL?10 and TNF?? polymorphisms and poor prognosis in Egyptian patients with ALL, while the IL?10 GG genotype may be associated with better survival in children with ALL.en_US
dc.identifier.affiliationsDepartment of Internal Medicine, Medical Oncology Unit, Mansoura University Oncology Center, Mansouraen_US
dc.identifier.affiliationsClinical Pathology Department, Hematology Unit, Mansoura Universityen_US
dc.identifier.affiliationsDepartment of Internal Medicine, Clinical Hematology Unit, Mansoura University Oncology Center, Mansouraen_US
dc.identifier.affiliationsDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura Universityen_US
dc.identifier.affiliationsDepartment of Pediatrics, Genetics Unit, Faculty of Medicine, Mansoura University, Egypten_US
dc.identifier.citationBaiomy Mohamed A. El, Akl Tamer, El-Menshawy Nadia, El?Sebaie Ahmed H., Morkos Hanna, El?Ashwah Shaimaa, El?Sabbagh Amr M., Wahba Yahya, El?Ghonemy Mohamed. The prognostic values of the IL?10 (G1082A) and TNF?? (G308A) polymorphisms in Egyptian patients with acute lymphoblastic leukemia: A single?center study. Indian Journal of Cancer . 2023 Jun; 60(2): 217-223en_US
dc.identifier.issn0019-509X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221780
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.4103/ijc.IJC_102_21en_US
dc.subjectAcute lymphoblastic leukemiaen_US
dc.subjectgene polymorphismsen_US
dc.subjectinterleukin?10en_US
dc.subjectprognosisen_US
dc.subjecttumor necrosis factor??en_US
dc.titleThe prognostic values of the IL?10 (G1082A) and TNF?? (G308A) polymorphisms in Egyptian patients with acute lymphoblastic leukemia: A single?center studyen_US
dc.typeJournal Articleen_US
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