Antioxidant vitamin levels in sickle cell disorders.

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dc.contributor.authorRay, Debesen_US
dc.contributor.authorDeshmukh, Pradeepen_US
dc.contributor.authorGoswami, Kalyanen_US
dc.contributor.authorGarg, Neelamen_US
dc.date.accessioned2007-01-15en_US
dc.date.accessioned2009-06-03T05:21:53Z
dc.date.available2007-01-15en_US
dc.date.available2009-06-03T05:21:53Z
dc.date.issued2007-01-15en_US
dc.description.abstractBACKGROUND: Sickle cell disorder is a haemoglobinopathy prevalent in the Vidharbha region of Maharashtra, central India. With recent evidence of oxidative stress in sickle haemoglobinopathy, a possible deficiency of antioxidant vitamins was suspected. METHODS: We measured plasma vitamin E, vitamin C and beta-carotene levels in persons with heterozygous (n=80) and homozygous sickle cell state (n=20), and suitable healthy controls for these groups (n=100 and 66, respectively) in a community-based study in the villages near our institution. RESULTS: Subjects with heterozygous sickle cell trait had lower vitamin E levels than their respective controls (p < 0.05). Subjects with homozygous sickle cell disease had lower levels of all three vitamins (p < 0.05). Vitamins E and C levels showed a significant positive correlation in both forms of sickle cell disorder. CONCLUSION: Our findings suggest that there is depletion of the antioxidant vitamins, particularly in severe forms of sickle cell disorder. A trial of administration of therapeutic doses of vitamin E in this condition is warranted.en_US
dc.description.affiliationMahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442102, Maharashtra.en_US
dc.identifier.citationRay D, Deshmukh P, Goswami K, Garg N. Antioxidant vitamin levels in sickle cell disorders. National Medical Journal of India. 2007 Jan-Feb; 20(1): 11-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/118318
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnemia, Sickle Cell --epidemiologyen_US
dc.subject.meshAntioxidants --analysisen_US
dc.subject.meshAscorbic Acid --blooden_US
dc.subject.meshAscorbic Acid Deficiencyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshVitamin E Deficiency --blooden_US
dc.subject.meshbeta Carotene --deficiencyen_US
dc.titleAntioxidant vitamin levels in sickle cell disorders.en_US
dc.typeJournal Articleen_US
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