Modulatory effects of diltiazem on inotropic responses to amrinone on rabbit isolated atria.

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dc.contributor.authorParhate, S Men_US
dc.contributor.authorThawani, V Ren_US
dc.contributor.authorMotghare, V Men_US
dc.contributor.authorDani, A Den_US
dc.contributor.authorParanjpe, B Den_US
dc.date.accessioned1998-04-04en_US
dc.date.accessioned2009-06-01T05:53:48Z
dc.date.available1998-04-04en_US
dc.date.available2009-06-01T05:53:48Z
dc.date.issued1998-04-04en_US
dc.description.abstractThe effect of pretreatment with graded concentration of diltiazem on the inotropic responses to amrinone were studied on isolated atria of rabbit. The responses to amrinone were modified by diltiazem in a biphasic manner; initial potentiation followed by inhibition. The potentiation is proposed to be due to synergistic rise in cytosolic calcium ion concentration by diltiazem and amrinone. The inhibition by diltiazem in higher concentration may be due to blockade of calcium ion influx and depletion of intracellular calcium ion from storage sites.en_US
dc.description.affiliationDepartment of Pharmacology, Govt. Medical College, Nagpur.en_US
dc.identifier.citationParhate SM, Thawani VR, Motghare VM, Dani AD, Paranjpe BD. Modulatory effects of diltiazem on inotropic responses to amrinone on rabbit isolated atria. Indian Journal of Physiology and Pharmacology. 1998 Apr; 42(2): 295-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106967
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAmrinone --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtrial Functionen_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshCardiotonic Agents --pharmacologyen_US
dc.subject.meshDiltiazem --pharmacologyen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshHeart Atria --drug effectsen_US
dc.subject.meshMyocardial Contraction --drug effectsen_US
dc.subject.meshPhosphodiesterase Inhibitors --pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.titleModulatory effects of diltiazem on inotropic responses to amrinone on rabbit isolated atria.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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