Rational antibiotics therapy in bacterial meningitis.

dc.contributor.authorDutta, A Ken_US
dc.contributor.authorBhatnagar, S Ken_US
dc.date.accessioned2001-07-01en_US
dc.date.accessioned2009-05-30T15:40:22Z
dc.date.available2001-07-01en_US
dc.date.available2009-05-30T15:40:22Z
dc.date.issued2001-07-01en_US
dc.description66 references.en_US
dc.description.abstractAcute bacterial meningitis is one of the most important causes of morbidity and mortality in developing countries. Though a wide range of antibiotics is available for therapy, judicious and rational use of antimicrobial agents needs to be ascertained. The choice of antimicrobial agents depends mainly on the age of the patient and its CSF penetrability. Neonatal meningitis is commonly caused by Gram Negative organisms such E. coli, Klebsiella and Pseudomans;Group B streptococciand Listeria, though other organisms like Staphylococcus sp. also contribute. The neonatal meningitis is best treated with a combination of amplicillin and a third generation cephalosporin given for 14-21 days. Post-neonatal meningitis usually occurs due to S. pneumoniae, N. meningitidis and H. influenzae and is best treated with third generation cephalosporins used with or without crystalline penicillin or ampicillin depending on the clinical situation. The therapy should be modified, if necessary, on availability of culture sensitivity report. The use of dexamethasone in meningitis due to the organisms other than H. influenzae still remains controversial.en_US
dc.description.affiliationDepartment of Pediatrics, Kalawati Saran Children's Hospital, Lady Hardinge Medical College, New Delhi.en_US
dc.identifier.citationDutta AK, Bhatnagar SK. Rational antibiotics therapy in bacterial meningitis. Indian Journal of Pediatrics. 2001 Jul; 68 Suppl 3(): S32-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/83841
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdrenal Cortex Hormones --therapeutic useen_US
dc.subject.meshAnti-Bacterial Agents --therapeutic useen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDrug Therapy, Combination --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMeningitis, Bacterial --drug therapyen_US
dc.titleRational antibiotics therapy in bacterial meningitis.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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