Osteopontin: A Novel Protein Molecule.

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dc.contributor.authorSase, Sudhir P
dc.contributor.authorNagane, Nitin
dc.contributor.authorGanu, Jayashree V
dc.date.accessioned2015-04-13T06:30:57Z
dc.date.available2015-04-13T06:30:57Z
dc.date.issued2012-02
dc.description.abstractOsteopontin (OPN) is phosphorylated sialic acid –rich non-collagenous bone matrix protein. OPN is found in several biological fluids including human plasma, serum, breast milk and urine.OPN was named for its function as a bridge between cells and minerals. OPN has been implicated as an important factor in bone remodeling. Osteopontin is expressed in immune cells, including macrophages, neutrophils, dendritic cells with varying kinetics. OPN influences cell mediated immunity and has Th 1 cytokine functions .OPN is overexpressed in cancers of lung, breast, colorectal, stomach and ovary.OPN is found in atheromatous plaques within arteries. OPN plays an important role during both acute and chronic inflammation. OPN is upregulated in tissues during several pathological process including atherosclerosis, valve stenosis, myocardial infarction and rheumatic arthritis. OPN is a key cytokine regulating tissue repair. OPN’s plasma levels are elevated in overweight and obesity.en_US
dc.identifier.citationSase Sudhir P, Nagane Nitin, Ganu Jayashree V. Osteopontin: A Novel Protein Molecule. Indian Medical Gazette. 2012 Feb ; 145 (2): 62-66.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157382
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ice/t12/i2/icet12i2p62.pdfen_US
dc.subjectosteopontin (opn)en_US
dc.subjectinflammationen_US
dc.subjectcanceren_US
dc.subjectbiomineralisationen_US
dc.subjectvascular calcificationen_US
dc.subjectobesityen_US
dc.subjectatherosclerosisen_US
dc.subject.meshAtherosclerosis
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshNeopalsms
dc.subject.meshObesity
dc.subject.meshOsteopontin --blood
dc.subject.meshOsteopontin --chemistry
dc.subject.meshOsteopontin --immunology
dc.subject.meshOsteopontin --metabolism
dc.subject.meshOsteopontin --physiology
dc.subject.meshOsteopontin --urine
dc.subject.meshVascular Calcification
dc.titleOsteopontin: A Novel Protein Molecule.en_US
dc.typeArticleen_US
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