A Study of the Clinical, Pathological and Radiological Profile of Lung Cancer in Non-Smokers

dc.contributor.authorSilpa, Kshetrimayumen_US
dc.contributor.authorVaskarjeet, Konsamen_US
dc.contributor.authorSrivastava, Ananden_US
dc.contributor.authorKant, Suryaen_US
dc.contributor.authorHusain, Nuzhaten_US
dc.date.accessioned2020-09-24T07:26:14Z
dc.date.available2020-09-24T07:26:14Z
dc.date.issued2019-09
dc.description.abstractAim and Objective: To study the clinical, pathological andradiological profile of lung cancer in non-smokers in a tertiarycare center.Methods: 53 non-smokers diagnosed with lung cancerattending the Department of Respiratory Medicine, KingGeorge’s Medical College from September 2015 to August2017 were enrolled. Record of all diagnostic investigations andprocedures performed namely transthoracic fine needleaspiration cytology (FNAC) and biopsy, bronchoscopy,thoracoscopy, closed pleural biopsy, lymph-node FNAC andbiopsy, routine blood and sputum examinations and a detailedhistory were obtained. Data was analysed retrospectively.Results: The mean age of presentation was 53.8±11.6 years.Majority were females (60.4%). Most common presentingsymptom was cough (84.9%). Mean duration of symptoms was6.9 months. Pallor was the most common clinical examinationfinding (41.5%). Mass with effusion was the most commonradiological lesion (45.3%). 22.6% masses were centrallylocated. Transthoracic biopsy could diagnose 32 (60.4%)cases. Adenocarcinoma was the most common type in bothmales (76.2%) and females (78.1%). Epidermal growth factorreceptor (EGFR) mutation was positive in 46.3% ofadenocarcinoma. Exon 19 deletion was the more commonmutation.Conclusion: Lung cancer among never smokers is a distinctclass with risk factors and genetic features discrete from thoseassociated with tobacco smoke. Indoor air pollutants as well asETS are definitely implicated risk factors. Targetable mutationsare commoner in non-smokers and hence mutation testingshould always be done in such patients. It is important toconduct studies about the diverse characteristics of this entityto consolidate our knowledge of this growing group of cancer.en_US
dc.identifier.affiliationsMD Respiratory Medicine, Senior Resident,Department of Respiratory Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India.en_US
dc.identifier.affiliations(Ex Junior Resident, Dept. of Respiratory Medicine, King George’s Medical College, Lucknow, UP, India.)en_US
dc.identifier.affiliationsMD Pathology, Consultant Pathologist,Department of Pathology, Shija Hospitals and Research Institute, Imphal, Manipur, India.en_US
dc.identifier.affiliationsMD Respiratory Medicine, Associate Professor,Department of Respiratory Medicine, King George’s Medical College, Lucknow, UP, India.en_US
dc.identifier.affiliationsMD Respiratory Medicine, Professor and Head,Department of Respiratory Medicine, King George’s Medical College, Lucknow, UP, India.en_US
dc.identifier.affiliationsMD Pathology, Professor and Head,Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, UP, India.en_US
dc.identifier.citationSilpa Kshetrimayum, Vaskarjeet Konsam, Srivastava Anand, Kant Surya, Husain Nuzhat. A Study of the Clinical, Pathological and Radiological Profile of Lung Cancer in Non-Smokers. International Journal of Medical Research Professionals. 2019 Sep; 5(5): 34-39en_US
dc.identifier.issn2454-6364
dc.identifier.issn2454-6356
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203478
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber5en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org//10..21276/ijmrp.2019.5.5.007en_US
dc.subjectNon-Smokeren_US
dc.subjectLung Canceren_US
dc.subjectAdenocarcinomaen_US
dc.subjectProfileen_US
dc.subjectEGFR.en_US
dc.titleA Study of the Clinical, Pathological and Radiological Profile of Lung Cancer in Non-Smokersen_US
dc.typeJournal Articleen_US
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