Lipid clinical trials with special reference to Indian population
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Date
2024-03
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Indians have a pattern of atherogenic dyslipidaemia characterised by not so high LDL-C but elevated small, dense LDL-C, elevated triglyceride levels and low HDL-C levels. In addition, different lipid-lowering drugs exhibit pharmacokinetic variability in Indians, which may have implications on the optimum doses required to achieve the desired LDL-C levels. Currently the management of dyslipidaemia in Indians are based on the landmark trials, which largely included western population. This review focusses on major clinical trials of lipid lowering drugs with special reference to the Indian population.
Description
Keywords
Dyslipidemia, Statins, PCSK-9 inhibitors, Icosapent ethyl, India
Citation
Basha Aseem, Ramakrishnan Sivasubramanian . Lipid clinical trials with special reference to Indian population. Indian Heart Journal. 2024 Mar; 76(1): 130-137