White matter hyperintensities on magnetic resonance imaging among elderly depressed patients and its association with the severity of depression and cognition

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dc.contributor.authorSoni, Ajitabhen_US
dc.contributor.authorSoni, Ravien_US
dc.contributor.authorSoni, Priyankaen_US
dc.date.accessioned2023-06-17T08:29:04Z
dc.date.available2023-06-17T08:29:04Z
dc.date.issued2022-07
dc.description.abstractIntroduction: Depression in the elderly can have a different pathophysiology and clinical profile, and studies have shown pathological changes in the brain on radio imaging. The present study aimed to find out the association of white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) with the severity of illness and cognition in elderly depressed patients. Methodology: This cross-sectional study included 68 elderly (>60 years of age) depressed patients who had undergone MRI at a tertiary care center, and based on the severity of WMH, they were divided into two groups: no or slight WMH group and moderate or severe WMH group. The severity of depression was assessed using the Hamilton Depression Rating Scale (HAM-D) scale, and neuropsychological assessments were made for testing attention, concentration and executive function. Results: HAM?D scores were found significantly higher in patients with moderate?to?severe WMH groups (22.6 ± 5.2) compared to those with no or slight WMH (16.3 ± 4.2). The cognitive performance evaluated by backward digit span test, Trail making Test A and B, and Color Stroop test was significantly poor in the moderate?to?severe WMH group. Conclusion: Elderly depressed patients having a greater WMH had more severe depression and poor cognitive performance, especially psychomotor and executive functioning. WMH could be a potential marker for the severity of illness and cognition in depression in elderly persons.en_US
dc.identifier.affiliationsDepartments of Psychiatry anden_US
dc.identifier.affiliationsBiochemistry, Pandit Deendayal Upadhyaya Medical College Churuen_US
dc.identifier.affiliationsDepartment of Radiodiagnosis, Pacific Medical College and Hospital, Udaipur, Rajasthan, Indiaen_US
dc.identifier.citationSoni Ajitabh, Soni Ravi, Soni Priyanka . White matter hyperintensities on magnetic resonance imaging among elderly depressed patients and its association with the severity of depression and cognition. Journal of the Indian Academy of Geriatrics. 2022 Jul; 18(3): 108-112en_US
dc.identifier.issn0974-3405
dc.identifier.issn0974-2484
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216428
dc.languageenen_US
dc.publisherThe Indian Academy of Geriatricsen_US
dc.relation.issuenumber3en_US
dc.relation.volume18en_US
dc.source.urihttps://doi.org/10.4103/jiag.jiag_31_22en_US
dc.subjectColor Stroopen_US
dc.subjectdigit span testen_US
dc.subjectHamilton depression rating scaleen_US
dc.subjectlate-life depressionen_US
dc.subjecttrail makingen_US
dc.titleWhite matter hyperintensities on magnetic resonance imaging among elderly depressed patients and its association with the severity of depression and cognitionen_US
dc.typeJournal Articleen_US
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