Influence of Hawthorn (Crataegus oxyacantha) Leaves Extract Administration on Myocardial Infarction Induced by Isoproterenol in Rats

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dc.contributor.authorSadek, Mona A.en_US
dc.contributor.authorMousa, Saharen_US
dc.contributor.authorEl-Masry, Shimaaen_US
dc.contributor.authorDemain, Amira M.en_US
dc.date.accessioned2019-12-06T09:42:11Z
dc.date.available2019-12-06T09:42:11Z
dc.date.issued2018-02
dc.description.abstractAims: To investigate the influence of ethanolic hawthorn leaves extract (EHLE) oral administration (200 mg / kg body weight /day) on isoproterenol (ISO) induced- myocardial infarction (MI) in rats and its bioactive constituents. Methods: Healthy adult male albino rats (Sprague-Dawely strain) were divided into five groups (10 rats /group); MI was induced in rats by ISO at a dose of {85 mg/kg body weight/day subcutaneously (S.C.,)} on two consecutive days with a 24 hours interval. Results: Pre-and post-treatment with EHLE significantly (p≤0.05) lowered the elevated serum cardiac enzyme marker activities namely, creatine kinase (CK), creatine kinase MB (CK- MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and specific MI markers level of galectin-3(Gal-3), cardiac troponin I (cTnI). Also, significantly (p≤0.05) ameliorated oxidant/ antioxidant status by decreasing oxidative stress biomarkers [tissue nitric oxide (NO), serum and tissue malondialdehyde (MDA)], and increasing antioxidant status [glutathione peroxidase (GPX), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH)] in ISO-injected rats. Microscopic examination of heart tissues confirmed these results. Conclusion: Our results demonstrated that EHLE has a cardioprotective effect against ISO-induced MI in rats due to its high antioxidant properties, inhibition of lipid peroxidation and restoration of cardiac enzyme activities.en_US
dc.identifier.affiliationsDepartment of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypten_US
dc.identifier.affiliationsDepartment of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypten_US
dc.identifier.affiliationsDepartment of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypten_US
dc.identifier.affiliationsDepartment of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypten_US
dc.identifier.citationSadek Mona A., Mousa Sahar, El-Masry Shimaa, Demain Amira M.. Influence of Hawthorn (Crataegus oxyacantha) Leaves Extract Administration on Myocardial Infarction Induced by Isoproterenol in Rats. Cardiology and Angiology: An International Journal. 2018 Feb; 7(1): 1-12en_US
dc.identifier.issn2347-520X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188677
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://doi.org/10.9734/CA/2018/39025en_US
dc.subjectIsoproterenolen_US
dc.subjectmyocardial infarctionen_US
dc.subjectbiomarkersen_US
dc.subjecthawthornen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidanten_US
dc.titleInfluence of Hawthorn (Crataegus oxyacantha) Leaves Extract Administration on Myocardial Infarction Induced by Isoproterenol in Ratsen_US
dc.typeJournal Articleen_US
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