Heritability estimation of conventional cardiovascular disease risk factors in Asian Indian families: The Calcutta family study.

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dc.contributor.authorGhosh, Arnab
dc.contributor.authorDutta, Rupak
dc.contributor.authorSarkar, Angshuman
dc.date.accessioned2012-06-08T08:20:06Z
dc.date.available2012-06-08T08:20:06Z
dc.date.issued2010-01
dc.description.abstractThe genetic causes of the components of cardiovascular disease (CVD) risk factors and their intercorrelation are indeed complex and only partly understood. Keeping this view in mind, the present work was undertaken to estimate the heritability of conventional CVD risk factors using family study method. A total of twenty-four nuclear families inhabiting in Calcutta and adjacent areas was chosen randomly. Up to first degree relatives including father, mother and other sibs of the proband were considered as participants in the study. Anthropometric measures namely height, weight, waist circumference as well as skinfold thickness at biceps, triceps, subscapular and suprailiac were obtained using standard techniques. Body mass index (BMI), percentage of body fat (PBF), fat mass (FM), waist-hip ratio (WHR), sum of four skinfolds (SF4 ), arm muscle circumference (AMC), arm muscle area (AMA), arm fat area (AFA), systolic (SBP) and diastolic blood pressure (DBP) were also considered. To estimate’heritability’ in the study, the mid parent-offspring model was used where’heritability’ (h2 ) was equivalent to regression co-efficient (b). The regression sum of square (RSS) and total sum of square (TSS) ratio was also calculated both for mid parent-offspring and single parent-offspring. This ratio was considered as a measure of’heritability’ in the study with consideration that RSS is the variation due to genetic factor and the TSS is due to genetic and other additive factor. It was observed that the estimated heritability for BMI ranges from 0.69 to 0.31 using mid-parent off spring model while the range using single parent-offspring model was from 0.40 to 0.16. The range of heritability for SBP in mid parent-offspring model was 0.16 to 0.44 and 0.05 to 0.54 for single parent-offspring model. To conclude, it seems reasonable to argue that in the study a moderate to high h2 was evident for body fat level, body composition and blood pressure measures which indicate a moderate to high aggregation of gene(s) in the family.en_US
dc.identifier.citationGhosh Arnab, Dutta Rupak, Sarkar Angshuman. Heritability estimation of conventional cardiovascular disease risk factors in Asian Indian families: The Calcutta family study. Indian Journal of Human Genetics. 2010 Jan; 16(1): 28-32.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138893
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927791/en_US
dc.subjectObesityen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectfamily studyen_US
dc.subjectheritabilityen_US
dc.subjectAsian Indiansen_US
dc.subject.meshAnthropometry --methods
dc.subject.meshAsian Continental Ancestry Group
dc.subject.meshCardiovascular Diseases --epidemiology
dc.subject.meshCardiovascular Diseases --etiology
dc.subject.meshCardiovascular Diseases --genetics
dc.subject.meshFamily
dc.subject.meshFemale
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshIndia --epidemiology
dc.subject.meshIndia --ethnology
dc.subject.meshMale
dc.subject.meshObesity --genetics
dc.subject.meshParents
dc.subject.meshPopulation Groups --genetics
dc.subject.meshRisk Factors
dc.titleHeritability estimation of conventional cardiovascular disease risk factors in Asian Indian families: The Calcutta family study.en_US
dc.typeArticleen_US
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