Bioaccessibility of Aflatoxin B₁ in Grinded Corn and Peanut by in vitro Digestion Model
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Date
2009-12-22
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Isan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสาน
Abstract
Aflatoxin B₁ (AFB₁) is a secondary metabolite produced principally by Aspergillus flavus and Aspergillus Parasiticus. This toxin represents a significant health hazard for those exposed to it continually for a prolonged period. Aflatoxigenic molds are commonly found in corn and peanuts, and under certain conditions aflatoxins will be formed. In vitro digestion is a method that has been used to estimate the bioaccessibility of chemicals and contaminants in foods. An in vitro digestion experiment was carried out in this study to analyze the bioaccessibility of AFB₁ in grinded corn and peanut. Trifluoroacetic acid-derivatized AFB₁ was measured using a HPLC-fluorescent detector. Results indicated that the bioaccessibility of AFB₁ in grinded corn and peanut was relatively high at 95% 94%, respectively. When AFB₁-contaminated grinded corn and peanut are ingested, most of the AFB₁ will be dissolved into chyme, with this strongly influencing the bioavailability of AFB₁ in humans. This may have important implications on dietary exposure. Findings from the current study could be applied to improve risk assessment of ingested AFB₁.
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Isan Journal of Pharmaceutical Sciences - วารสารเภสัชศาสตร์อีสาน; Volume 5 No.2 May-August 2009; 108-113