Effects of Leaf Extracts from Piper sarmentosum Roxb., Lagerstroemia speciosa (L.) Per. and Centella asiatica (L.) Urban. on Blood Glucose Level, Chemistry of Urine, Histology of Small Intestine and Hematological Values in Diabetic Rats

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dc.contributor.authorThippawan Pilaen_US
dc.contributor.authorChusri Talubmooken_US
dc.contributor.authorSanong Chomkoen_US
dc.date.accessioned2011-02-21T06:53:39Z
dc.date.available2011-02-21T06:53:39Z
dc.date.created2010-02-15en_US
dc.date.issued2010-02-15en_US
dc.description.abstractThis research was aimed to investigate the effects of ethanolic leaf extracts from Piper sarmentosum Roxb., Lagerstroemia spesiosa (L.) Per. and Centella asiatica (L.) Urban. on blood glucose levels, urine volume and chemical properties, histology of small intestine and hematological values in diabetic rats. The experiments were conducted by daily and oral feeding the leaf extracts from these three plants at the dose of 250 mg/kg to streptozotocin-induced diabetic rats for eight weeks. The results showed that all the extracts used could reduce blood glucose levels and increase in the body weight gain. The extract from  Lagerstroemia spesiosa (L.) Per leaves reduced blood glucose levels (58.06±3.49%) greater than the extract from  Centella asiatica  (L.) Urban. leaves (23.03±9.09%). The extract from Piper sarmentosum Roxb. leaves reduced blood glucose levels in early 3 weeks of experiment. The feature of small intestine tissues from Piper sarmentosum Roxb., Lagerstroemia spesiosa (L.) Per. and Centella asiatica (L.) Urban. were not different from normal and glibenclamide treated. Moreover, all of extracts exerted any alteration of % hematocrit, g % hemoglobin, red blood cell and white blood cell count were not different but significantly higher (p \< 0.05) than diabetic group. Urine volume and chemical properties of all extract treated rats were not different from control and glibenclamide treatments. These findings indicated the leaf extracts from Piper sarmentosum Roxb., Lagerstroemia spesiosa (L.) Per. and Centella asiatica (L.) Urban. can be used for lowering blood glucose level but had no effect on volume and chemical properties of urine, histology of small intestine and hematological values in diabetic rats.en_US
dc.identifier.citationJournal of Science and Technology Mahasarakham University - วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยมหาสารคาม; Volume 27 Number 1 January-March 2008; 33-40en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/131154
dc.language.isoen_USen_US
dc.publisherJournal of Science and Technology Mahasarakham University - วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยมหาสารคามen_US
dc.rightsDivision of Research Supporting and Extension, Mahasarakham University, Mahasarakham, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JSTMU/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/JSTMU/article/view/1649en_US
dc.titleEffects of Leaf Extracts from Piper sarmentosum Roxb., Lagerstroemia speciosa (L.) Per. and Centella asiatica (L.) Urban. on Blood Glucose Level, Chemistry of Urine, Histology of Small Intestine and Hematological Values in Diabetic Ratsen_US
dc.typeResearch Articlesen_US
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Journal of Science and Technology Mahasarakham University - วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยมหาสารคาม