Mother-to-child transmission of HIV among women who chose not to exclusively breastfeed their infants in Pune, India.

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dc.contributor.authorGupta, Amitaen_US
dc.contributor.authorGupte, Nikhilen_US
dc.contributor.authorSastry, Jayagowrien_US
dc.contributor.authorBharucha, Kapila Een_US
dc.contributor.authorBhosale, Rameshen_US
dc.contributor.authorKulkarni, Poorvaen_US
dc.contributor.authorTripathy, Srikanthen_US
dc.contributor.authorNayak, Umaen_US
dc.contributor.authorPhadke, Mridulaen_US
dc.contributor.authorBollinger, Robert Cen_US
dc.contributor.author,en_US
dc.date.accessioned2007-08-13en_US
dc.date.accessioned2009-05-27T06:24:59Z
dc.date.available2007-08-13en_US
dc.date.available2009-05-27T06:24:59Z
dc.date.issued2007-08-13en_US
dc.description.abstractBACKGROUND & OBJECTIVE: The percentage of HIV cases attributed to mother-to-child transmission (MTCT) has increased several fold in recent years. No reports are available on HIV MTCT rates among HIV-infected choosing not be exclusively breastfeed their infants in India. We examined HIV MTCT rates among 41 Indian women in a prospective cohort who chose predominantly not to exclusively breastfeed. METHODS: Of the 41 women, 27 (66%) received MTCT prophylaxis: 3 received short course zidovudine (AZT), 19 single-dose nevirapine (NVP), and 5 both AZT and NVP. Maternal HIV-I RNA levels (viral load) were measured at the time of delivery. Infants were tested for HIV-1 infection by PCR up to 11 times is first year of life and viral load was measured in PCR positive infants. RESULTS: All infants received single dose NVP. Thirty two (76%) infants were exclusively formula-fed, 10 (24%) were mixed fed. Four infants were diagnosed with HIV infection for an overall 12- month transmission probability of 8 per cent [95% confidence interval (CI) of 3.2 to 22.1%]. Restricting analysis to 31 women who exclusively formula-fed, only one (3.1%) transmission event occurred. The 41 HIV-infected women gave birth to 42 live-born infants. INTERPRETATION & CONCLUSION: Our data from a small cohort of HIV-infected women suggest that short-course AZT or single dose NVP are effective in reducing MTCT in an Indian setting. Larger studies are needed to assess HIV MTCT rates in India, but in this small study rates were comparable to that observed among women who chose not to exclusively breastfeed in other resource-limited settings.en_US
dc.description.affiliationDivision of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. agupta25@jhmi.eduen_US
dc.identifier.citationGupta A, Gupte N, Sastry J, Bharucha KE, Bhosale R, Kulkarni P, Tripathy S, Nayak U, Phadke M, Bollinger RC, . Mother-to-child transmission of HIV among women who chose not to exclusively breastfeed their infants in Pune, India. Indian Journal of Medical Research. 2007 Aug; 126(2): 131-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16112
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-HIV Agents --therapeutic useen_US
dc.subject.meshBottle Feedingen_US
dc.subject.meshBreast Feedingen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Infections --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInfectious Disease Transmission, Vertical --prevention & controlen_US
dc.subject.meshNevirapine --administration & dosageen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Infectious --drug therapyen_US
dc.subject.meshZidovudine --administration & dosageen_US
dc.titleMother-to-child transmission of HIV among women who chose not to exclusively breastfeed their infants in Pune, India.en_US
dc.typeClinical Trial, Phase IIIen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, N.I.H., Extramuralen_US
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