Neurophysiology of pain: insight to orofacial pain.

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dc.contributor.authorTandon, O Pen_US
dc.contributor.authorMalhotra, Ven_US
dc.contributor.authorTandon, Sen_US
dc.contributor.authorD'Silva, Ien_US
dc.date.accessioned2003-07-16en_US
dc.date.accessioned2009-06-01T05:43:48Z
dc.date.available2003-07-16en_US
dc.date.available2009-06-01T05:43:48Z
dc.date.issued2003-07-16en_US
dc.description104 references.en_US
dc.description.abstractThis is a very exciting time in the field of pain research. Major advances are made at every level of analysis from development to neural plasticity in the adult and from the transduction of a noxious stimulus in a primary afferent neuron to the impact of this stimulus on cortical circuitry. The molecular identity of nociceptors, their stimulus transduction processes and the ion channels involved in the generation, modulation and propagation of action potentials along the axons in which these nociceptors are present are being vigorously perused. Similarly tremendous progress has occurred in the identification of the receptors, transmitters, second messenger systems, transcription factors, and signaling molecules underlying the neural plasticity observed in the spinal cord and brainstem after tissue or nerve injury. With recent insight into the pharmacology of different neural circuits, the importance of descending modulatory systems in the response of the nervous system to persistent pain after injury is being reevaluated. Finally, imaging studies revealed that information about tissue damage is distributed at multiple forebrain sites involved in attentional, motivational, and cognitive aspects of the pain experience.en_US
dc.description.affiliationDepartment of Physiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110 095.en_US
dc.identifier.citationTandon OP, Malhotra V, Tandon S, D'Silva I. Neurophysiology of pain: insight to orofacial pain. Indian Journal of Physiology and Pharmacology. 2003 Jul; 47(3): 247-69en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106838
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEndarterectomy, Carotiden_US
dc.subject.meshHumansen_US
dc.subject.meshPostoperative Careen_US
dc.subject.meshPostoperative Complications --therapyen_US
dc.subject.meshTriageen_US
dc.subject.meshVascular Surgical Proceduresen_US
dc.titleNeurophysiology of pain: insight to orofacial pain.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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