Female pattern hair loss.

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dc.contributor.authorSingal, Archana
dc.contributor.authorSonthalia, Sidharth
dc.contributor.authorVerma, Prashant
dc.date.accessioned2013-10-16T06:33:06Z
dc.date.available2013-10-16T06:33:06Z
dc.date.issued2013-09
dc.description.abstractFemale pattern hair loss (FPHL) is a common cause of hair loss in women characterized by diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline. Its prevalence increases with advancing age and is associated with significant psychological morbidity. The pathophysiology of FPHL is still not completely understood and seems to be multifactorial. Although androgens have been implicated, the involvement of androgen-independent mechanisms is evident from frequent lack of clinical or biochemical markers of hyperandrogenism in affected women. The role of genetic polymorphisms involving the androgen and estrogen receptors is being increasingly recognized in its causation and predicting treatment response to anti-androgens. There are different clinical patterns and classifications of FPHL, knowledge of which facilitates patient management and research. Chronic telogen effluvium remains as the most important differential diagnosis. Thorough history, clinical examination, and evaluation are essential to confirm diagnosis. Patients with clinical signs of androgen excess require assessment of biochemical parameters and imaging studies. It is prudent to screen the patients for metabolic syndrome and cardiovascular risk factors. The treatment comprises medical and/or surgical modalities. Medical treatment should be initiated early as it effectively arrests hair loss progression rather than stimulating regrowth. Minoxidil continues to be the first line therapy whereas anti-androgens form the second line of treatment. The progressive nature of FPHL mandates long-term treatment for sustained effect. Medical therapy may be supplemented with cosmetic concealment in those desirous of greater hair density. Surgery may be worthwhile in some carefully selected patients.en_US
dc.identifier.citationSingal Archana, Sonthalia Sidharth, Verma Prashant. Female pattern hair loss. Indian Journal of Dermatology, Venereology and Leprology. 2013 Sept-Oct; 79(5): 626-640.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/148755
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2013;volume=79;issue=5;spage=626;epage=640;aulast=Singalen_US
dc.subjectAndrogenetic alopeciaen_US
dc.subjectanti-androgen therapyen_US
dc.subjectfemale pattern hair lossen_US
dc.subjectfinasterideen_US
dc.subjectgenetic pre-dispositionen_US
dc.subjecthyperandrogenismen_US
dc.subjectminoxidilen_US
dc.subject.mesh5-alpha Reductase Inhibitors --therapeutic use
dc.subject.meshAlopecia --diagnosis
dc.subject.meshAlopecia --drug therapy
dc.subject.meshAlopecia --genetics
dc.subject.meshAndrogen Antagonists --therapeutic use
dc.subject.meshFemale
dc.subject.meshFinasteride --therapeutic use
dc.subject.meshHumans
dc.subject.meshMinoxidil --therapeutic use
dc.subject.meshVasodilator Agents --therapeutic use
dc.titleFemale pattern hair loss.en_US
dc.typeArticleen_US
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