Management of triglycerides, non-high density lipoprotein cholesterol and high density lipoprotein cholesterol

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dc.contributor.authorZachariah, Geevaren_US
dc.date.accessioned2025-05-09T07:17:52Z
dc.date.available2025-05-09T07:17:52Z
dc.date.issued2024-03
dc.description.abstractDyslipidaemia characterised by elevated total cholesterol/LDL-C, triglyceride or both or decreased HDL-C is an important risk factor for the development of ASCVD. Atherogenic dyslipidaemia characterised by high TG, low HDL-C and elevated small dense LDL (sdLDL) is more prevalent in Asian Indians. Normal level of TG is generally considered as <150 mg/dl. Hypertriglyceridemia is closely associated with obesity, metabolic syndrome and diabetes mellitus. Goals of management of hypertriglyceridemia are to lower the risk of atherosclerotic car- diovascular events and reduce the risk of pancreatitis. Lifestyle modification is important. In severe hyper- triglyceridemia, TG lowering pharmacotherapy is important to prevent pancreatitis. In mild to moderate hypertriglyceridemia, pharmacotherapy is employed only if associated with ASCVD or high risk factors and not controlled with lifestyle modifications and statins. Non-High Density Lipoprotein Cholesterol which estimates the cholesterol content of the atherogenic apoB containing lipoproteins, measured as total cholesterol minus HDL-C is equivalent to LDL-C in ASCVD risk assessment and superior to it in those with mild to moderate hypertriglyceridemia. Some international guide- lines, have included measurement of non-HDL-C as primary therapeutic target for patients with ASCVD. Low HDL cholesterol is common in Indians. Despite evidence of inverse relationship between HDL-C and cardiovascular events, HDL-C as a causative factor for development of atherosclerosis is unproven. Therapeutic strategies directed at increasing HDL-C levels have not been shown to have cardiovascular benefits and hence HDL-C is currently not a target for drug-based treatmenten_US
dc.identifier.affiliationsMother Heart Care, Mother Hospital, Thrissur, Kerala, Indiaen_US
dc.identifier.citationZachariah Geevar . Management of triglycerides, non-high density lipoprotein cholesterol and high density lipoprotein cholesterol. Indian Heart Journal. 2024 Mar; 76(1): 58-64en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242767
dc.languageenen_US
dc.publisherElsevieren_US
dc.relation.issuenumber1en_US
dc.relation.volume76en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2023.11.004en_US
dc.subjectHypertriglyceridemiaen_US
dc.subjectNon-HDL-Cholesterolen_US
dc.subjectHDL-Cholesterolen_US
dc.subjectDyslipidemiaen_US
dc.subjectIndian Dyslipidemiaen_US
dc.titleManagement of triglycerides, non-high density lipoprotein cholesterol and high density lipoprotein cholesterolen_US
dc.typeJournal Articleen_US
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