Ceftriaxone prophylaxis in cardiovascular surgery in children.

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dc.contributor.authorSueblinvong, Ven_US
dc.contributor.authorSanpradit, Men_US
dc.date.accessioned2009-05-27T19:52:45Z
dc.date.available2009-05-27T19:52:45Z
dc.date.issued1989-04-01en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractFifty patients undergoing closed and open heart surgery were prospectively studied for the effectiveness of peri-operative prophylaxis with Ceftriaxone. Twenty-four patients (Gr I) that underwent closed heart surgery received 50 mg/kg single dose of Ceftriaxone given intravenously at the start of anesthesia. Twenty-six patients (Gr II) that underwent open heart surgery received 50 mg/kg. Ceftriaxone given intravenously at the start of anesthesia followed by another 50 mg/kg 24 hours later. The mean duration of surgery in Gr I was 1.7 hours and Gr II was 4.2 hours. The duration of post-operative fever in Gr I ranged from 0-4 days (mean 2.4) and Gr II ranged from 1-13 days (mean 6). The duration of post-operative hospitalization in Gr I ranged from 5-18 days (mean 9) and Gr II ranged from 7-71 days (mean 19). Early and late infectious complications were not found in Gr I. Late infectious complications were not found in Gr I. Late infectious complications in Gr II consisted of 2 cases of pneumonitis, 5 pleural effusions and 1 staphylococcus aureus would infection (36.8%). We concluded that a single dose of Ceftriaxone should provide adequate prophylaxis for closed heart surgery. An additional 2-3 days of daily dose Ceftriaxone may be needed when associated with tissue hypoxia, longer duration of intravenous lines and drainage tubes in open heart surgery.en_US
dc.identifier.citationSueblinvong V, Sanpradit M. Ceftriaxone prophylaxis in cardiovascular surgery in children. Journal of the Medical Association of Thailand. 1989 Apr; 72(4): 218-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/41962
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshCeftriaxone --therapeutic useen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Defects, Congenital --surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshPremedicationen_US
dc.subject.meshRespiratory Tract Infections --prevention & controlen_US
dc.subject.meshSurgical Wound Infection --prevention & controlen_US
dc.subject.meshUrinary Tract Infections --prevention & controlen_US
dc.titleCeftriaxone prophylaxis in cardiovascular surgery in children.en_US
dc.typeJournal Articleen_US
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