Immunohistochemical localization of transferrin in human breast cancer tissue.

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dc.contributor.authorAgarwal, P Ken_US
dc.contributor.authorMehrotra, Aen_US
dc.contributor.authorChandra, Ten_US
dc.contributor.authorSingh, Ken_US
dc.date.accessioned2001-04-09en_US
dc.date.accessioned2009-05-29T13:20:34Z
dc.date.available2001-04-09en_US
dc.date.available2009-05-29T13:20:34Z
dc.date.issued2001-04-09en_US
dc.description.abstractThe present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors. The distribution of transferrin has been studied in 153 cases (63 benign lesions and 90 malignant tumors). The extent of staining reaction was determined by semiquantitative grading (weak, moderate and consistent). Positivity rate for transferrin was higher (92.2%) in malignant tumors as compared to benign breast lesions (28.5%) with significant p value (P = .0001) for both the groups. The intensity was variable in both the groups, being more intense in the malignant tumors. Tumors with higher grade of malignancy presented consistent positive staining along with the lymph nodes involved. The extent of immunoreactivity revealed a significant positive correlation with axillary lymph node status. However, no significant correlation was found with the age of the patients. Thus the study of transferrin in breast tumors besides being of prognostic significance helps in the further management of malignant lesions of the breast.en_US
dc.description.affiliationDepartment of Pathology, Institute of Clinical Epidemiology, King George's Medical College, Lucknow.en_US
dc.identifier.citationAgarwal PK, Mehrotra A, Chandra T, Singh K. Immunohistochemical localization of transferrin in human breast cancer tissue. Indian Journal of Pathology & Microbiology. 2001 Apr; 44(2): 107-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75547
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshBreast Neoplasms --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTransferrin --metabolismen_US
dc.subject.meshTumor Markers, Biological --metabolismen_US
dc.titleImmunohistochemical localization of transferrin in human breast cancer tissue.en_US
dc.typeJournal Articleen_US
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